IEE Proceedings - Nanobiotechnology

IEE Proceedings - Nanobiotechnology

Online ISSN 1740-9748
Print ISSN 1478-1581

Published from 2003-2006, IEE Proceedings - Nanobiotechnology covered all aspects of research and emerging nanobiological technologies including: fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale; micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology; nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications; colloid chemistry applied to nanobiotechnology; microtechnologies such as Lab-on-Chip applied to pharmaceutical, biomedical and biotechnological applications; techniques for probing cell physiology, cell adhesion sites and cell-cell communication; molecular self-assembly; and societal issues.

This publication is continued by IET Nanobiotechnology 2007-. ISSN 1751-8741. more..

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Absorption detection of enzymatic reaction using optical microfluidics based intermittent flow microreactor system
- Author(s): A. Chandrasekaran and M. Packirisamy
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- p. 137 –143 (7)
  The advantages of integrating microfluidics into photonics-based biosensing for fabricating microreactor type lab-on-a-chip devices carries a lot of advantages, such as smaller sample volume handling, controlled drug delivery and high throughput diagnosis, which is useful for in situ medical diagnosis and point-of-care (POC) testing. A hybrid integrated optical microfluidic system has been developed for the study of single molecules and enzymatic reactions. The method of optical absorption has been employed for biosensing and the feasibility of absorption-based detection on the microfluidic platform has been demonstrated using horseradish peroxidase and hydrogen peroxide, as an example. The results show that the device is useful for the analysis of both the individual chemical specimen and also the study of chemical and biological reaction between two reacting species. The hybrid integration of microfluidics and optical ensembles thus forms the basis for developing the microreactor type lab-on-a-chip device, which would have several important applications in the area of nanobiotechnology.
Dynamics of rotating paramagnetic particles simulated by lattice Boltzmann and particle dynamics methods
- Author(s): A. Yadav ; R. Calhoun ; P.E. Phelan ; A.K. Vuppu ; A.A. Garcia ; M. Hayes
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- p. 145 –150 (6)
  Novel biochemical sensors consisting of rotating chains of microscale paramagnetic particles have been proposed that would enable convenient, sensitive analyte detection. Predicting the dynamics of these particles is required to optimise their design. The results of lattice Boltzmann (LB) and particle dynamics (PD) simulations are reported, where the LB approach provides a verified solution of the complete Navier-Stokes equations, including the hydrodynamic interactions among the particles. On the other hand, the simpler PD approach neglects hydrodynamic interactions, and does not compute the fluid motion. It is shown that macroscopic properties, like the number of aggregated particles, depend only on the drag force and not on the total hydrodynamic force, making PD simulations yield reasonably accurate predictions. Relatively good agreement between the LB and PD simulations, and qualitative agreement with experimental data, are found for the number of aggregated particles as a function of the Mason number. The drag force on a rotating cylinder is significantly different from that on particle chains calculated from both simulations, demonstrating the different dynamics between the two cases. For microscopic quantities like the detailed force distributions on each particle, the complete Navier-Stokes solution, here represented by the LB simulation, is required.

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IEE Proceedings - Nanobiotechnology

Volumes & issues:

Volume 153 (2006)

Volume 152 (2005)

Volume 151 (2004)

Volume 150 (2003)

Latest content

Absorption detection of enzymatic reaction using optical microfluidics based intermittent flow microreactor system

Dynamics of rotating paramagnetic particles simulated by lattice Boltzmann and particle dynamics methods

Most viewed content for this Journal

Most cited content for this Journal