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Regulatory modules that generate biphasic signal response in biological systems

Regulatory modules that generate biphasic signal response in biological systems

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  • Author(s): A. Levchenko 1 ; J. Bruck 2 ; P.W. Sternberg 3
    • View affiliations
    • Affiliations: 1: Whitaker Institute for Biomedical Engineering, Johns Hopkins University, Baltimore, USA
      2: Division of Engineering and Applied Science, California Institute of Technology, Pasadena, USA
      3: Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, USA
  • Source: Volume 1, Issue 1, June 2004, p. 139 – 148
    DOI:  10.1049/sb:20045014 , Print ISSN 1741-2471, Online ISSN 1741-248X
IEE
Published

Biochemical networks might be composed of modules. It is still not clear how biochemical modules can be defined and characterised. Here we propose a functional approach to module definition, considering different classes of biphasic regulation modules, which effect optimal cell response to intermediate signal strength. Each regulation class might possess unique properties that make it especially suitable for particular biological functions.

Inspec keywords: molecular biophysics; biocontrol; biochemistry; cellular biophysics

Other keywords: intermediate signal strength; module definition; biological systems; optimal cell response; biphasic signal response; biochemical networks; regulatory modules

Subjects: Systems theory applications in biology and medicine; Molecular biophysics

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