In this study, using the lung cancer cells (A549) as the model cell line, the authors proposed a facile method to prepare uniform-sized cancer cell membrane (Ccm) vehicle, which was then employed to load the photothermal agent indocyanine green (ICG) for effective cancer photothermal therapy (PTT). The as-prepared Ccm/ICG was demonstrated to have a uniform particle size of around 100 nm, which was capable of targeting the A549 cells through Ccm-mediated endocytosis. As a result, the Ccm/ICG increased the cellular uptake of Ce6 into A549 cells as compared to free ICG and potentiated the PTT efficacy both in vitro and in vivo, which might be a promising drug delivery system for advanced cancer therapy.

References

1. 1)
  - 6. Zhang, S., Pang, G., Chen, C., et al: ‘Effective cancer immunotherapy by ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response’, Carbohydr. Polym., 2019, 205, pp. 192–202 (doi: 10.1016/j.carbpol.2018.10.028).
2. 2)
  - 29. Yang, J., Teng, Y., Fu, Y., et al: ‘Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer’, Int. J. Nanomed., 2019, 14, p. 5061 (doi: 10.2147/IJN.S202910).
3. 3)
  - 8. Li, L., Yang, S., Song, L., et al: ‘An endogenous vaccine based on fluorophores and multivalent immunoadjuvants regulates tumor micro-environment for synergistic photothermal and immunotherapy’, Theranostics, 2018, 8, (3), p. 860 (doi: 10.7150/thno.19826).
4. 4)
  - 10. Chen, Z., Zhao, P., Luo, Z., et al: ‘Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy’, ACS Nano, 2016, 10, (11), pp. 10049–10057 (doi: 10.1021/acsnano.6b04695).
5. 5)
  - 15. Zhu, Y., Yu, F., Tan, Y., et al: ‘Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells’, Theranostics, 2019, 9, (23), pp. 6764–6779 (doi: 10.7150/thno.36334).
6. 6)
  - 22. Tang, D., Zhao, X., Yang, T., et al: ‘Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy’, RSC Adv., 2018, 8, (1), pp. 380–389 (doi: 10.1039/C7RA07796C).
7. 7)
  - 11. Fang, R.H., Hu, C.M., Luk, B.T., et al: ‘Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery’, Nano Lett., 2014, 14, (4), pp. 2181–2188 (doi: 10.1021/nl500618u).
8. 8)
  - 24. Liu, X., Wang, C., Ma, H., et al: ‘Water-responsive hybrid nanoparticles codelivering ICG and DOX effectively treat breast cancer via hyperthermia-aided DOX functionality and drug penetration’, Adv. Healthc. Mater., 2019, 8, (8), p. 1801486 (doi: 10.1002/adhm.201801486).
9. 9)
  - 12. Byun, D.J., Wolchok, J.D., Rosenberg, L.M., et al: ‘Cancer immunotherapy – immune checkpoint blockade and associated endocrinopathies’, Nat. Rev. Endocrinol., 2017, 13, (4), p. 195 (doi: 10.1038/nrendo.2016.205).
10. 10)
  - 30. Zhang, Y., Cheng, M., Cao, J., et al: ‘Multivalent nanoparticles for personalized theranostics based on tumor receptor distribution behavior’, Nanoscale., 2019, 11, (11), pp. 5005–5013 (doi: 10.1039/C8NR09347D).
11. 11)
  - 4. Jahanban-Esfahlan, R., de la Guardia, M., Ahmadi, D., et al: ‘Modulating tumor hypoxia by nanomedicine for effective cancer therapy’, J. Cell. Physiol., 2018, 233, (3), pp. 2019–2031 (doi: 10.1002/jcp.25859).
12. 12)
  - 28. Egloff-Juras, C., Bezdetnaya, L., Dolivet, G., et al: ‘NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green’, Int. J. Nanomed., 2019, 14, p. 7823 (doi: 10.2147/IJN.S207486).
13. 13)
  - 2. Mok, T.S., Wu, Y.-L., Ahn, M.-J., et al: ‘Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer’, N. Engl. J. Med., 2017, 376, (7), pp. 629–640 (doi: 10.1056/NEJMoa1612674).
14. 14)
  - 27. Tang, Y., Li, Y., Li, S., et al: ‘Transformable nanotherapeutics enabled by ICG: towards enhanced tumor penetration under NIR light irradiation’, Nanoscale, 2019, 11, (13), pp. 6217–6227 (doi: 10.1039/C9NR01049A).
15. 15)
  - 3. Kumar, S.U., Kumar, V., Priyadarshi, R., et al: ‘pH-responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy’, Carbohydr. Polym., 2018, 188, pp. 252–259 (doi: 10.1016/j.carbpol.2018.02.006).
16. 16)
  - 20. Wang, C., Han, M., Liu, X., et al: ‘Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy’, Int. J. Nanomed., 2019, 14, pp. 1503–1517 (doi: 10.2147/IJN.S193976).
17. 17)
  - 25. Ingato, D., Edson, J.A., Zakharian, M., et al: ‘Cancer cell-derived, drug-loaded nanovesicles induced by sulfhydryl-blocking for effective and safe cancer therapy’, ACS Nano, 2018, 12, (9), pp. 9568–9577 (doi: 10.1021/acsnano.8b05377).
18. 18)
  - 17. Zhao, M., Xu, Y., Xie, M., et al: ‘Halogenated aza-BODIPY for imaging-guided synergistic photodynamic and photothermal tumor therapy’, Adv. Healthcare Mater., 2018, 7, (18), p. 1800606 (doi: 10.1002/adhm.201800606).
19. 19)
  - 18. Xu, G., Bao, X., Chen, J., et al: ‘In vivo tumor photoacoustic imaging and photothermal therapy based on supra-(carbon nanodots)’, Adv. Healthcare Mater., 2019, 8, (2), p. 1800995 (doi: 10.1002/adhm.201800995).
20. 20)
  - 14. Golchin, S., Alimohammadi, R., Rostami Nejad, M., et al: ‘Synergistic antitumor effect of anti-PD-L1 combined with oxaliplatin on a mouse tumor model’, J. Cell. Physiol., 2019, 234, (11), pp. 19866–19874 (doi: 10.1002/jcp.28585).
21. 21)
  - 31. Xie, W., Zhu, S., Yang, B., et al: ‘The destruction of laser-induced phase-transition nanoparticles triggered by low-intensity ultrasound: an innovative modality to enhance the immunological treatment of ovarian cancer cells’, Int. J. Nanomed., 2019, 14, p. 9377 (doi: 10.2147/IJN.S208404).
22. 22)
  - 1. Li, Z., Wu, H., Yang, M., et al: ‘Stability mechanism of O/W pickering emulsions stabilized with regenerated cellulose’, Carbohydr. Polym., 2018, 181, pp. 224–233 (doi: 10.1016/j.carbpol.2017.10.080).
23. 23)
  - 16. Peng, J., Xiao, Y., Li, W., et al: ‘Photosensitizer micelles together with IDO inhibitor enhance cancer photothermal therapy and immunotherapy’, Adv. Sci., 2018, 5, (5), p. 1700891 (doi: 10.1002/advs.201700891).
24. 24)
  - 5. Cao, L., Zhang, H., Zhou, Z., et al: ‘Fluorophore-free luminescent double-shelled hollow mesoporous silica nanoparticles as pesticide delivery vehicles’, Nanoscale, 2018, 10, (43), pp. 20354–20365 (doi: 10.1039/C8NR04626C).
25. 25)
  - 21. Pan, H., Sun, Y., Cao, D., et al: ‘Low-density lipoprotein decorated and indocyanine green loaded silica nanoparticles for tumor-targeted photothermal therapy of breast cancer’, Pharm. Dev. Technol., 2020, 25, (3), pp. 308–315 (doi: 10.1080/10837450.2019.1684944).
26. 26)
  - 19. Duan, M., Xia, F., Li, T., et al: ‘Matrix metalloproteinase-2-targeted superparamagnetic Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes for dual-mode imaging and photodynamic therapy’, Nanoscale, 2019, 11, (39), pp. 18426–18435 (doi: 10.1039/C9NR06774D).
27. 27)
  - 26. Zhang, J., Miao, Y., Ni, W., et al: ‘Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma’, Artif. Cells Nanomed. Biotechnol., 2019, 47, (1), pp. 2298–2305 (doi: 10.1080/21691401.2019.1622554).
28. 28)
  - 13. Nie, D., Dai, Z., Li, J., et al: ‘Cancer-cell-membrane-coated nanoparticles with a yolk–shell structure augment cancer chemotherapy’, Nano Lett., 2019, 20, (2), pp. 936–946 (doi: 10.1021/acs.nanolett.9b03817).
29. 29)
  - 23. Yang, D., Yang, G., Sun, Q., et al: ‘Carbon-dot-decorated TiO2 nanotubes toward photodynamic therapy based on water-splitting mechanism’, Adv. Healthc. Mater., 2018, 7, (10), p. 1800042 (doi: 10.1002/adhm.201800042).
30. 30)
  - 7. Zhao, X., Tang, D., Wu, Y., et al: ‘An artificial cell system for biocompatible gene delivery in cancer therapy’, Nanoscale, 2020, 12, (18), pp. 10189–10195 (doi: 10.1039/C9NR09131A).
31. 31)
  - 9. Liu, L.H., Qiu, W.X., Zhang, Y.H., et al: ‘A charge reversible self-delivery chimeric peptide with cell membrane-targeting properties for enhanced photodynamic therapy’, Adv. Funct. Mater., 2017, 27, (25), p. 1700220 (doi: 10.1002/adfm.201700220).

Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer

References

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