access icon free Non-enzymatic electrochemical detection of dopamine in blood serum based on porous nitrogen-doped graphene/Fe3O4 nanocomposites

Fe3O4 with different shapes are reported herein to modify the glassy carbon electrode and then they are used to detect dopamine (DA), a member of the catecholamine and phenethylamine families. Cyclic voltammetry, electrochemical impedance spectroscopy, differential pulse voltammetry and linear sweep voltammetry are all chosen to characterise the sensor's performance to DA. Under the optimal conditions, the modified sensor (N-rGO/Fe3O4 NRs/GCE) had some good performance, followed as short response time (∼3 s), wide linear range (0.2–176 μM), low detection limit (0.05 μM, S/N = 2), good stability and reproducibility. The fabricated DA biosensor was further investigated for DA determination in human blood serum, suggesting its great potential in biological samples.

Inspec keywords: graphene compounds; nanocomposites; chemical variables measurement; voltammetry (chemical analysis); electrochemical impedance spectroscopy; biomedical transducers; nanofabrication; nanosensors; biomedical electrodes; biosensors; electrochemical sensors; electrochemical electrodes; biological techniques; nanoporous materials; iron compounds

Other keywords: human blood serum; catecholamine families; C-Fe3O4-CO:N; electrochemical impedance spectroscopy; linear sweep voltammetry; differential pulse voltammetry; DA biosensor; dopamine detection; phenethylamine families; cyclic voltammetry; nanocomposites; glassy carbon electrode; nonenzymatic electrochemical detection

Subjects: Biosensors; Chemical sensors; Methods of nanofabrication and processing; Chemical sensors; Biological engineering and techniques; Electrochemistry and electrophoresis; Sensing and detecting devices; Micromechanical and nanomechanical devices and systems; Patient diagnostic methods and instrumentation; Biosensors; Electrochemical analytical methods; Chemical variables measurement; Microsensors and nanosensors; Nanometre-scale semiconductor fabrication technology; Biomedical measurement and imaging

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http://iet.metastore.ingenta.com/content/journals/10.1049/mnl.2020.0121
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