An enzyme-free glucose electrochemical sensor with high sensitivity and selectivity is highly attractive. In this work, an enzyme-free glucose sensor with Cu₂O hollow microspheres (Cu₂O HMs) was prepared via hydrothermal method. The glucose sensor constructed by the prepared Cu₂O HM structure exhibited a low detection limit of 0.13 μM, a high sensitivity of 277.1 μA/mM cm², and the wide linear ranges of 0.05–1.5 and 1.5–6.0 mM. Furthermore, anti-interference tests indicated that the prepared sensor exhibited good selectivity for glucose and practical application in human serum. The Cu₂O sensor has great application potential in the development of enzyme-free glucose sensor.

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Cu₂O hollow microspheres as electrode materials for non-enzymatic electrochemical detection of glucose

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Cu2O hollow microspheres as electrode materials for non-enzymatic electrochemical detection of glucose

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Cu₂O hollow microspheres as electrode materials for non-enzymatic electrochemical detection of glucose