Cu2O hollow microspheres as electrode materials for non-enzymatic electrochemical detection of glucose
- Author(s): Fan Zhang 1 ; Yihui Wang 1 ; Xiujuan Wu 1 ; Hao Zhang 1 ; Shan Huang 1 ; Ying Yang 1 ; Adi Xie 1 ; Mingyan Wang 1
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View affiliations
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Affiliations:
1:
Department of Chemical Engineering , Jiangsu Ocean University , Lianyungang 222005 , People's Republic of China
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Affiliations:
1:
Department of Chemical Engineering , Jiangsu Ocean University , Lianyungang 222005 , People's Republic of China
- Source:
Volume 15, Issue 15,
30
December
2020,
p.
1071 – 1074
DOI: 10.1049/mnl.2020.0030 , Online ISSN 1750-0443
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An enzyme-free glucose electrochemical sensor with high sensitivity and selectivity is highly attractive. In this work, an enzyme-free glucose sensor with Cu2O hollow microspheres (Cu2O HMs) was prepared via hydrothermal method. The glucose sensor constructed by the prepared Cu2O HM structure exhibited a low detection limit of 0.13 μM, a high sensitivity of 277.1 μA/mM cm2, and the wide linear ranges of 0.05–1.5 and 1.5–6.0 mM. Furthermore, anti-interference tests indicated that the prepared sensor exhibited good selectivity for glucose and practical application in human serum. The Cu2O sensor has great application potential in the development of enzyme-free glucose sensor.
Inspec keywords: microsensors; electrochemical sensors; sugar; chemical variables measurement; copper compounds; microelectrodes
Other keywords: enzyme-free glucose electrochemical sensor; antiinterference testing; electrode materials; hydrothermal method; CuO2; hollow microspheres; HM structure; nonenzymatic electrochemical detection
Subjects: Chemical sensors; Chemical sensors; Sensing and detecting devices; MEMS and NEMS device technology; Microsensors and nanosensors; Micromechanical and nanomechanical devices and systems; Chemical variables measurement
References
-
-
1)
-
7. Chang, G., Shu, H., Huang, Q., et al: ‘Synthesis of highly dispersed Pt nanoclusters anchored graphene composites and their application for non-enzymatic glucose sensing’, Electrochim. Acta, 2015, 157, pp. 149–157 (doi: 10.1016/j.electacta.2015.01.085).
-
-
2)
-
13. Luo, Z.J., Han, T.T., Qu, L.L., et al: ‘A ultrasensitive nonenzymatic glucose sensor based on Cu2O polyhedrons modified Cu electrode’, Chin. Chem. Lett., 2012, 23, pp. 953–956 (doi: 10.1016/j.cclet.2012.06.003).
-
-
3)
-
28. Liu, M.M., Ru, L., Wei, C., et al: ‘Graphene wrapped Cu2O nanocubes: non-enzymatic electrochemical sensors for the detection of glucose and hydrogen peroxide with enhanced stability’, Biosens. Bioelectron., 2013, 45, pp. 206–212 (doi: 10.1016/j.bios.2013.02.010).
-
-
4)
-
23. Guo, C., Wang, Y., Zhao, Y., et al: ‘Non-enzymatic glucose sensor based on three dimensional nickel oxide for enhanced sensitivity’, Anal. Methods, 2013, 5, pp. 1644–1647 (doi: 10.1039/c3ay00067b).
-
-
5)
-
27. Felix, S., Kollu, P., Raghupathy, B.P.C., et al: ‘Electrocatalytic activity of Cu2O nanocubes-based electrode for glucose oxidation’, J. Chem. Sci., 2014, 126, pp. 25–32 (doi: 10.1007/s12039-013-0564-x).
-
-
6)
-
25. Zhang, X.M., Li, K.Z., Li, H.J., et al: ‘Electrochemical sensing of ethylenediamine based on cuprous oxide/graphene hybrid structures’, J. Mater. Sci., 2015, 50, pp. 4288–4299 (doi: 10.1007/s10853-015-8981-5).
-
-
7)
-
24. Yan, X.Y., Yang, J., Ma, L., et al: ‘Size-controlled synthesis of Cu2O nanoparticles on reduced graphene oxide sheets and their application as non-enzymatic glucose sensor materials’, J. Solid State Electrochem., 2015, 19, pp. 3195–3199 (doi: 10.1007/s10008-015-2911-y).
-
-
8)
-
2. Scognamiglio, V.: ‘Nanotechnology in glucose monitoring: advances and challenges in the last 10 years’, Biosens. Bioelectron., 2013, 47, pp. 12–25 (doi: 10.1016/j.bios.2013.02.043).
-
-
9)
-
12. Ma, J.W., Wang, J., Wang, M., et al: ‘Preparation of cuprous oxide mesoporous spheres with different pore sizes for non-enzymatic glucose detection’, Nanomaterials, 2018, 8, pp. 73–81 (doi: 10.3390/nano8020073).
-
-
10)
-
18. Wang, P., Ng, Y.H., Amal, R., et al: ‘Embedment of anodized p-type Cu2O thin films with CuO nanowires for improvement in photoelectrochemical stability’, Nanoscale, 2013, 5, pp. 2952–2958 (doi: 10.1039/c3nr34012k).
-
-
11)
-
8. Cao, H., Yang, A., Li, H., et al: ‘A non-enzymatic glucose sensing based on hollow cuprous oxide nanospheres in a Nafion matrix’, Sens. Actuators B Chem., 2015, 214, pp. 169–173 (doi: 10.1016/j.snb.2015.03.026).
-
-
12)
-
10. Gao, Z., Liu, J., Chang, J., et al: ‘Mesocrystalline Cu2O hollow nanocubes: synthesis and application in non-enzymatic amperometric detection of hydrogen peroxide and glucose’, Cryst. EngComm., 2012, 14, pp. 6639–6646 (doi: 10.1039/c2ce25498k).
-
-
13)
-
9. Zhang, L., Li, H., Ni, Y., et al: ‘Porous cuprous oxide microcubes for non-enzymatic amperometric hydrogen peroxide and glucose sensing’, Electrochem. Commun., 2009, 11, pp. 812–815 (doi: 10.1016/j.elecom.2009.01.041).
-
-
14)
-
19. Cong, Y.Q., Ge, Y.H., Zhang, T.T., et al: ‘Fabrication of Z-scheme Fe2O3-MoS2-Cu2O ternary nanofilm with significantly enhanced photoelectrocatalytic performance’, Ind. Eng. Chem. Res., 2018, 57, pp. 881–890 (doi: 10.1021/acs.iecr.7b04089).
-
-
15)
-
4. Si, P., Huang, Y., Wang, T., et al: ‘Nanomaterials for electrochemical non-enzymatic glucose biosensors’, RSC Adv., 2013, 3, pp. 3487–3502 (doi: 10.1039/c2ra22360k).
-
-
16)
-
26. Li, S., Zheng, Y., Qin, G.W., et al: ‘Enzyme-free amperometric sensing of hydrogen peroxide and glucose at a hierarchical Cu2O modified electrode’, Talanta, 2011, 85, pp. 1260–1264 (doi: 10.1016/j.talanta.2011.05.033).
-
-
17)
-
5. Park, S., Boo, H., Chung, T.D., et al: ‘Electrochemical non-enzymatic glucose sensors’, Anal. Chim. Acta, 2006, 556, pp. 46–57 (doi: 10.1016/j.aca.2005.05.080).
-
-
18)
-
11. Lu, W.D., Sun, Y.J., Dai, H.C., et al: ‘Direct growth of pod-like Cu2O nanowire arrays on copper foam: highly sensitive and efficient nonenzymatic glucose and H2O2 biosensor’, Sens. Actuators B Chem., 2016, 231, pp. 860–866 (doi: 10.1016/j.snb.2016.03.058).
-
-
19)
-
14. Feng, L.L., Zhang, C.L., Gao, G., et al: ‘Facile synthesis of hollow Cu2O octahedral and spherical nanocrystals and their morphology-dependent photocatalytic properties’, Nanoscale Res. Lett., 2012, 7, pp. 276–285 (doi: 10.1186/1556-276X-7-276).
-
-
20)
-
3. Dong, X.C., Xu, H., Wang, X.W., et al: ‘3d graphene-cobalt oxide electrode for high-performance supercapacitor and enzymeless glucose detection’, ACS Nano, 2012, 6, pp. 3206–3213 (doi: 10.1021/nn300097q).
-
-
21)
-
22. Khan, R., Ahmad, R., Rai, P., et al: ‘Glucose-assisted synthesis of Cu2O shuriken-like nanostructures and their application as nonenzymatic glucose biosensors’, Sens. Actuators B Chem., 2014, 203, pp. 471–476 (doi: 10.1016/j.snb.2014.06.128).
-
-
22)
-
1. Mitro, N., Mak, P.A., Vargas, L., et al: ‘The nuclear receptor LXR is a glucose sensor’, Nature, 2007, 445, pp. 219–223 (doi: 10.1038/nature05449).
-
-
23)
-
6. Yuan, M., Liu, A., Zhao, M., et al: ‘Bimetallic PdCu nanoparticle decorated three-dimensional graphene hydrogel for non-enzymatic amperometric glucose sensor’, Sens. Actuators B Chem., 2014, 190, pp. 707–714 (doi: 10.1016/j.snb.2013.09.054).
-
-
24)
-
21. Wang, J., Zhang, W.D.: ‘Fabrication of CuO nanoplatelets for highly sensitive enzyme-free determination of glucose’, Electrochim. Acta, 2011, 56, pp. 7510–7516 (doi: 10.1016/j.electacta.2011.06.102).
-
-
25)
-
16. Wang, X.J., Feng, J., Bai, Y.C., et al: ‘Synthesis, properties, and applications of hollow micro-/nanostructures’, Chem. Rev., 2016, 116, pp. 10983–11060 (doi: 10.1021/acs.chemrev.5b00731).
-
-
26)
-
15. Cao, M., Hu, C., Wang, Y., et al: ‘A controllable synthetic route to Cu, Cu2O, and CuO nanotubes and nanorods’, Chem. Commun., 2003, 15, pp. 1884–1885 (doi: 10.1039/b304505f).
-
-
27)
-
17. Li, C.R., Yao, J., Huang, Y., et al: ‘Salt-templated growth of monodisperse hollow nanostructures’, J. Mater. Chem. A, 2019, 7, pp. 1404–1409 (doi: 10.1039/C8TA11318A).
-
-
1)