Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

Ezzat Hamdy Elshazly; Lizhen Yu; Yue Zhang; Hui Wang; Kuanmin Chen; Song Zhang; Lixia Ke; Renmin Gong

Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

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Author(s): Ezzat Hamdy Elshazly^{1, 2} ; Lizhen Yu^{1, 3} ; Yue Zhang^{1, 4} ; Hui Wang¹ ; Kuanmin Chen¹ ; Song Zhang¹ ; Lixia Ke¹ ; Renmin Gong¹
- Affiliations: 1: College of Life Science, Anhui Normal University , Wuhu, 241000 , People's Republic of China ;
  2: Department of Botany and Microbiology, Faculty of Science , Al Azhar University , Assiut, 71524 , Egypt ;
  3: School of pharmacy, Wannan Medical College , Wuhu, 241002 , People's Republic of China ;
  4: School of Forensic Medicine, Wannan Medical College , Wuhu, 241002 , People's Republic of China
Source: Volume 14, Issue 10, 04 September 2019, p. 1111 – 1116
DOI: 10.1049/mnl.2019.0080 , Online ISSN 1750-0443

Received 31/01/2019, Accepted 24/06/2019, Revised 03/05/2019, Published 04/09/2019

In this work, folate-phytosterol-carboxymethyl cellulose nanoparticles (FPCMC NPs) derived from plant material were fabricated and investigated as carrier of hydrophobic anticancer drugs. Firstly, hydrophobic phytosterol was grafted onto the framework of water-soluble carboxymethyl cellulose. Then folate, as tumor-targeting ligand, was coupled to the phytosterol-carboxymethyl cellulose to become self-assembled FPCMC NPs. The physicochemical properties of the fabricated FPCMC NPs were characterized. Doxorubicin (DOX) was selected as model anticancer drug that was entrapped in prepared FPCMC NPs with satisfactory loading content (7%) and loading efficiency (71.2%). The in vitro drug release test showed that the release amount of DOX from drug-loaded FPCMC NPs at pH 5.3 was much higher than that at pH 6.5 or pH 7.4. The research results indicated that the fabricated FPCMC NPs had the potential as nanocarrier of hydrophobic anticancer drugs for further experimental study.

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Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

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