© The Institution of Engineering and Technology
Magnetite nanoparticles (MNPs) were synthesised and grafted with polymer containing brilliant cresyl blue for the exchange of losartan potassium. The resulted polymeric nanoparticles were characterised with Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis and transmission electron microscopy. The effects of the exchange parameters such as sample pH, temperature and contact time on sorption of losartan potassium were investigated. The sorption capacity of the functionalised sorbent was 19.4 mg g−1. The equilibrium adsorption data of losartan potassium on modified nanoparticles were analysed by Langmuir, Freundlich, Temkin, Dubinin–Radushkevich and Redlich–Peterson equations. Nearly, 74% of losartan potassium was released in simulated gastric fluid of pH 1.2 in 15 h and 50% in simulated intestinal fluid pH 7.4 in 30 h. These results have shown the utility of losartan potassium loaded–modified MNPs for enteric drug delivery.
References
-
-
1)
-
10. Veiseh, O., Gunn, J.W., Zhang, M.: ‘Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging’, Adv. Drug Deliv. Rev., 2010, 62, pp. 284–304 (doi: 10.1016/j.addr.2009.11.002).
-
2)
-
14. Mahdavian, A.R., Mirrahimi, M.A.S.: ‘Efficient separation of heavy metal cations by anchoring polyacrylic acid on superparamagnetic magnetite nanoparticles through surface modification’, Chem. Eng. J., 2010, 159, pp. 264–271 (doi: 10.1016/j.cej.2010.02.041).
-
3)
-
2. Darwish, I.A.: ‘Analytical study for the charge-transfer complexes of losartan potassium’, Anal. Chim. Acta, 2005, 549, pp. 212–220 (doi: 10.1016/j.aca.2005.06.023).
-
4)
-
20. Ho, Y., Ofomaja, A.E.: ‘Biosorption thermodynamics of cadmium on coconut copra meal as biosorbent’, Biochem. Eng. J., 2006, 30, pp. 117–123 (doi: 10.1016/j.bej.2006.02.012).
-
5)
-
11. Sun, C., Lee, J.S.H., Zhang, M.: ‘Magnetic nanoparticles in MR imaging and drug delivery’, Adv. Drug Deliv. Rev., 2008, 60, pp. 1252–1265 (doi: 10.1016/j.addr.2008.03.018).
-
6)
-
1. Etcheverry, S.B., Ferrer, E.G., Naso, L., et al: ‘Losartan and its interaction with copper(II): biological effects’, Bioorg. Med. Chem., 2007, 15, pp. 6418–6424 (doi: 10.1016/j.bmc.2007.06.056).
-
7)
-
13. Kumar, C.S.S.R., Mohammad, F.: ‘Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery’, Adv. Drug Deliv. Rev., 2011, 63, pp. 789–808 (doi: 10.1016/j.addr.2011.03.008).
-
8)
-
12. Ai, H.: ‘Layer-by-layer capsules for magnetic resonance imaging and drug delivery’, Adv. Drug Deliv. Rev., 2011, 63, pp. 772–788 (doi: 10.1016/j.addr.2011.03.013).
-
9)
-
5. Hertzog, D.L., McCafferty, J.F., Fang, X., et al: ‘Development and validation of a stability-indicating HPLC method for the simultaneous determination of losartan potassium, hydrochlorothiazide, and their degradation products’, J. Pharm. Biomed. Anal., 2002, 30, pp. 747–760 (doi: 10.1016/S0731-7085(02)00385-0).
-
10)
-
8. Euliss, L.E., Grancharov, S.G., Obrien, S., et al: ‘Cooperative assembly of magnetic nanoparticles and block copolypeptides in aqueous media’, Nano Lett., 2003, 3, (11), pp. 1489–1493 (doi: 10.1021/nl034472y).
-
11)
-
6. Lastra, O.C., Lemus, I.G., Sanchez, H.J., et al: ‘Development and validation of an UV derivative spectrophotometric determination of losartan potassium in tablets’, J. Pharm. Biomed. Anal., 2003, 33, pp. 175–180 (doi: 10.1016/S0731-7085(03)00347-9).
-
12)
-
4. Seburg, R.A., Ballard, J.M., Hwang, T.L., et al: ‘Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation’, J. Pharm. Biomed. Anal., 2006, 42, pp. 411–422 (doi: 10.1016/j.jpba.2006.04.030).
-
13)
-
19. Dubinin, M.M., Radushkevich, L.V.: ‘Equation of the characteristic curve of activated charcoal’, Chem. Zent., 1947, 1, (1), pp. 75–882.
-
14)
-
31. Langmuir, I.: ‘The adsorption of gases on plane surfaces of glass, mica and platinum’, J. Am. Chem. Soc., 1918, 40, pp. 1361–1402 (doi: 10.1021/ja02242a004).
-
15)
-
3. Brunetto, M.R., Contreras, Y., Clavijo, S., et al: ‘Determination of losartan, telmisartan, and valsartan by direct injection of human urine into a column-switching liquid chromatographic system with fluorescence detection’, J. Pharm. Biomed. Anal., 2009, 50, pp. 194–199 (doi: 10.1016/j.jpba.2009.04.015).
-
16)
-
7. Williams, R.C., Alasandro, V.L., Fasone, V.L., et al: ‘Comparison of liquid chromatography, capillary electrophoresis and super-critical fluid chromatography in the determination of losartan potassium drug substance in Cozaar tablets’, J. Pharm. Biomed. Anal., 1996, 14, pp. 1539–1546 (doi: 10.1016/0731-7085(96)01740-2).
-
17)
-
9. Gao, Q., Liang, Q., Yub, F., et al: ‘Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system’, Colloids Surf. B, Biointerfaces, 2011, 88, pp. 741–748 (doi: 10.1016/j.colsurfb.2011.08.010).
-
18)
-
17. Freundlich, H.M.F.: ‘Over the adsorption in solution’, J. Phys. Chem., 1906, 57, pp. 385–471.
-
19)
-
18. Temkin, M.J., Pyzhev, V.: ‘Recent modifications to langmuir isotherms’, Acta Physicochim. URSS, 1940, 12, pp. 217–222.
-
20)
-
16. Hall, K.L., Eagleton, L.C., Acrivos, A., et al: ‘Pore and solid-diffusion kinetics in fixed bed adsorption under constant pattern conditions’, Ind. Eng. Chem. Fundam., 1966, 5, pp. 212–218 (doi: 10.1021/i160018a011).
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