Fabrication and characterisation of new type of magnetic nanoanion exchanger particles for enteric losartan potassium delivery

Fabrication and characterisation of new type of magnetic nanoanion exchanger particles for enteric losartan potassium delivery

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Magnetite nanoparticles (MNPs) were synthesised and grafted with polymer containing brilliant cresyl blue for the exchange of losartan potassium. The resulted polymeric nanoparticles were characterised with Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis and transmission electron microscopy. The effects of the exchange parameters such as sample pH, temperature and contact time on sorption of losartan potassium were investigated. The sorption capacity of the functionalised sorbent was 19.4 mg g−1. The equilibrium adsorption data of losartan potassium on modified nanoparticles were analysed by Langmuir, Freundlich, Temkin, Dubinin–Radushkevich and Redlich–Peterson equations. Nearly, 74% of losartan potassium was released in simulated gastric fluid of pH 1.2 in 15 h and 50% in simulated intestinal fluid pH 7.4 in 30 h. These results have shown the utility of losartan potassium loaded–modified MNPs for enteric drug delivery.

Inspec keywords: Fourier transform infrared spectra; drug delivery systems; drugs; adsorption; nanofabrication; polymer blends; biomedical materials; iron compounds; nanoparticles; pH; filled polymers; magnetic particles; scanning electron microscopy; nanomedicine; thermal analysis; nanocomposites; nanomagnetics; transmission electron microscopy; potassium compounds; ion exchange

Other keywords: Fourier transform infrared spectroscopy; enteric losartan potassium delivery; thermogravimetric analysis; sample pH; losartan potassium loaded–modified MNPs; polymeric nanoparticles; enteric drug delivery; time 15.0 hour; graft polymer; exchange parameters; magnetite nanoparticles; simulated gastric fluid; Dubinin-Radushkevich equations; Freundlich equations; Fe2O3; simulated intestinal fluid; transmission electron microscopy; equilibrium adsorption data; Langmuir analysis; magnetic nanoanion exchanger particles; time 30.0 hour; elemental analysis; contact time; brilliant cresyl blue; Redlich-Peterson equations; functionalised sorbent

Subjects: Sorption and accommodation coefficients (surface chemistry); Patient care and treatment; Magnetic properties of nanostructures; Infrared and Raman spectra and scattering (condensed matter); Chemical exchanges (substitution, atom transfer, abstraction, disproportionation, and group exchange); Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Fine-particle magnetic systems; Biomedical materials; Amorphous and nanostructured magnetic materials; Adsorption and desorption kinetics; evaporation and condensation; Electrochemistry and electrophoresis; Nanotechnology applications in biomedicine


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