access icon free Synthesis of magnetite (Fe3O4)–Avastin nanocomposite as a potential drug for AMD treatment

Age-related macular degeneration (AMD) is one of the prevailing causes of blindness in the aged over 50 years. There are several conventional treatments for AMD including laser therapy, surgery, and intravitreal injection of anti-vascular endothelial growth factor directly into the eye. Intravitreal injection may result in various side effects such as increasing the eye pressure, eye infections, blurring vision; furthermore, it can negatively affect other body organs. In addition, large number of injections would be required to regenerate the lost vision. To overcome some of these obstacles, the work proposes a new drug delivery technique by using Avastin–Fe3O4 nanocomposites synthesised through co-precipitation method with approximate size of 20 nm. The saturation magnetisation (M s) of the synthesised iron oxide nanoparticles (NPs) was about 55.6648 emu/g which is completely suitable for movement of the (Avastin–Fe3O4) NPs. Besides, the results of the flow cytometry tests showed that 90.5% of NPs were Avastin loaded. The proposed new method can be replaced with conventional treatments as the long-term sustained release of Avastin instead of several injections as well as declining the systemic side effects due to the high concentration of Avastin in the posterior segment of the eye.

Inspec keywords: nanomedicine; molecular biophysics; nanofabrication; surgery; nanomagnetics; magnetisation; cellular biophysics; laser applications in medicine; drug delivery systems; precipitation (physical chemistry); vision defects; nanocomposites; eye; iron compounds; drugs; biomedical materials; nanoparticles

Other keywords: co-precipitation method; synthesised iron oxide nanoparticles; blurring vision; age-related macular degeneration; macular degeneration; AMD treatment; drug delivery technique; lost vision; surgery; body organs; flow cytometry; intravitreal injection; antivascular endothelial growth factor; systemic side effects; laser therapy; eye infections; Fe3O4; saturation magnetisation; blindness; eye pressure; magnetite–Avastin nanocomposite synthesis

Subjects: Biomedical materials; Nanotechnology applications in biomedicine; Magnetization curves, hysteresis, Barkhausen and related effects; Cellular biophysics; Methods of nanofabrication and processing; Patient care and treatment

References

    1. 1)
http://iet.metastore.ingenta.com/content/journals/10.1049/mnl.2017.0820
Loading

Related content

content/journals/10.1049/mnl.2017.0820
pub_keyword,iet_inspecKeyword,pub_concept
6
6
Loading