access icon free Nucleosides analogues recognition by molecularly imprinted polymer-coated Love wave sensor

© The Institution of Engineering and Technology
Received 18/04/2013, Accepted 31/05/2013, Published

Presented is a process for thin film molecularly imprinted polymer (MIP) coating based on commercial nucleotides adenosine monophosphate (AMP). The compatibility of the MIP film with acoustic propagation and sensor sensitivity for rebinding of AMP have been verified. Thin and porous layers of AMP-based MIP layers were successfully deposited on the sensor surface. Detection tests of AMP have been performed in aqueous media. The sensor response was recorded in terms of frequency and total insertion losses after both steps: AMP extraction from MIP then AMP rebinding. The sensor showed high sensitivity to 25 ppm AMP concentration. The effect of the extraction time on rebinding capacity of the MIP layer has been proven.

Inspec keywords: polymer films; porous materials; acoustic devices; Love waves; coatings; thin film sensors; biomedical equipment; acoustic wave propagation

Other keywords: adenosine monophosphate; acoustic propagation; AMP concentration; MIP film; molecularly imprinted polymer-coated Love wave sensor; AMP-based MIP layers; aqueous media; porous layers; AMP rebinding; nucleotides; acoustic sensor; rebinding capacity

Subjects: Patient diagnostic methods and instrumentation; Sonic and ultrasonic equipment; Sonic and ultrasonic radiation (medical uses); Sonic and ultrasonic radiation (biomedical imaging/measurement); Sensing devices and transducers; Sensing and detecting devices

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