Towards optimised wireless Love wave biosensor with high sensitivity

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Towards optimised wireless Love wave biosensor with high sensitivity

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Published

A Love wave biosensor, which is composed of a one-port surface acoustic wave reflective delay line on a piezoelectric substrate, a thin overlayer (waveguide layer) on top of the substrate, and a sensitive film that responds only to a specific cell, was optimally designed on a 41° YX LiNbO3 substrate and then fabricated according to the extracted design parameters. Based on multilayer theory, polymethylmethacrylate waveguide thickness was optimised. For derivation of the coupling of mode parameters, the periodic using the periodic finite-element method/boundary element method modelling was utilised. Optimal interdigital transducers and reflectors' features were determined to realise high-quality reflection peaks. The experimentally measured reflection coefficient S11 showed good agreement with simulated results. The evaluated sensitivity was 11.5 deg/µg/ml in terms of anti-DNP immunoglobulin G absorption.

Inspec keywords: Love waves; lithium compounds; piezoelectric materials; biomedical transducers; biosensors; polymer structure; boundary-elements methods; optimisation; finite element analysis; bioacoustics; surface acoustic wave devices; wireless sensor networks

Other keywords: optimal interdigital transducers; periodic finite-element method/boundary element method modelling; waveguide layer; one-port surface acoustic wave reflective delay line; reflection coefficient; LiNbO3; polymethylmethacrylate waveguide thickness; anti-DNP immunoglobulin G absorption; thin overlayer; piezoelectric substrate; wireless Love wave biosensor; multilayer theory

Subjects: Piezoelectricity and electrostriction; Finite element analysis; Transduction; devices for the generation and reproduction of sound; Piezoelectric and ferroelectric materials; Acoustic wave devices; Sonic and ultrasonic radiation (biomedical imaging/measurement); Biosensors; Wireless sensor networks; Structure of polymers, elastomers, and plastics; Biosensors; Sonic and ultrasonic transducers and sensors; Sonic and ultrasonic radiation (medical uses); Numerical approximation and analysis; Patient diagnostic methods and instrumentation; Acoustical measurements and instrumentation; Optimisation techniques

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