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access icon openaccess Fabrication of micro-patterned titanium dioxide nanotubes thin film and its biocompatibility

This is an open access article published by the IET under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/)
Received 16/10/2014, Accepted 20/10/2014, Revised 19/10/2014, Published 24/10/2014

In this study, in order to obtain a novel biomaterials surface which possesses the functions of an anticoagulant, inhibiting smooth muscle proliferation and pro-endothelialisation simultaneously, a micro-patterned titanium dioxide (TiO2)-nanotubes (P-TiO2-nanotubes) thin film was prepared on titanium (Ti) surface by photolithography combining with anodising method. The authors found that the P-TiO2-nanotubes could reduce platelet attachment and conformational change of fibrinogen (FGN) as well as promoting endothelial cells (ECs) growth compared with the TiO2-nanotubes. Notably, P-TiO2-nanotubes could significantly reduce smooth muscle cells (SMCs) proliferation compared with TiO2-nanotubes and TiO2, and the ECs and SMCs cultured on the P-TiO2-nanotubes thin film were elongated, which was suggested to be beneficial for maintaining the cell function. Therefore it is suggested that the P-TiO2-nanotubes thin film can contribute more to biocompatible functions of regulating and coordinating the behaviour of platelets, ECs and SMCs.

Inspec keywords: titanium compounds; cellular biophysics; nanofabrication; thin films; nanotubes; nanobiotechnology

Other keywords: micropatterned titanium dioxide nanotubes thin film; proendothelialisation; anticoagulant; cell function; photolithography; smooth muscle proliferation; TiO2; biocompatibility; endothelial cells growth; biomaterials surface

Subjects: Cellular biophysics; Low-dimensional structures: growth, structure and nonelectronic properties; Methods of nanofabrication and processing; Nanotechnology applications in biomedicine

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