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Sensors made of RNA: tailored ribozymes for detection of small organic molecules, metals, nucleic acids and proteins

Sensors made of RNA: tailored ribozymes for detection of small organic molecules, metals, nucleic acids and proteins

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Published

Nucleic acids are well suited to serve as biosensors for the fast and reliable detection of small organic molecules, such as a number of metabolites or antibiotics, specific nucleic acid sequences, peptides, proteins or metal ions. One of the main advantages of using nucleic acids as biosensors is that they can be modulated to respond allosterically to specific effectors. Thus molecular recognition is transformed directly into a catalytic process with observable results. In particular, catalytic RNA structures, such as the hammerhead and hairpin ribozymes, have been used for biosensor engineering. The review reports on the function mode of nucleic acid biosensors and introduces recent developments and applications in the field.

Inspec keywords: biosensors; reviews; biochemistry; catalysis; enzymes; molecular biophysics

Other keywords: small organic molecule detection; hairpin ribozymes; catalysis; biosensors; RNA sensors; review; molecular recognition; metals detection; nucleic acid detection; hammerhead; tailored ribozymes; protein detection; biosensor engineering

Subjects: Reviews and tutorial papers; resource letters; Physical chemistry of biomolecular solutions and condensed states; Biosensors

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