Cell response to nano-islands produced by polymer demixing: a brief review
Cell response to nano-islands produced by polymer demixing: a brief review
- Author(s): M.J. Dalby ; D. Pasqui ; S. Affrossman
- DOI: 10.1049/ip-nbt:20040534
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- Author(s): M.J. Dalby 1 ; D. Pasqui 2 ; S. Affrossman 3
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View affiliations
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Affiliations:
1: Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
2: Department of Chemical and Biosystem Sciences and technologies, Università di Siena V. Moro, 2 Sienna, Italy
3: Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK
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Affiliations:
1: Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
- Source:
Volume 151, Issue 2,
April 2004,
p.
53 – 61
DOI: 10.1049/ip-nbt:20040534 , Print ISSN 1478-1581, Online ISSN 1740-9748
This review looks at the present literature available regarding cell response to nano-islands produced by nanotopography. Polymer demixing is a chemical method of fabricating large areas of nanotopography quickly and cheaply, making it ideal for cell testing and thus allowing it to be one of the first well-researched methods in cell engineering. The review shows that cells respond strongly to the islands (cell types observed include endothelial cells, fibroblasts, osteoblasts, leucocytes and platelets). Such changes include differences in adhesion, growth, gene expression and morphology.
Inspec keywords: island structure; nanostructured materials; polymer structure; nanotechnology; reviews; biomedical materials; polymer films; cellular biophysics; adhesion; surface topography; polymer blends; tissue engineering
Other keywords: cell response; nano-islands; gene expression; cell testing; tissue engineering; cell engineering; fibroblasts; cell growth; osteoblasts; cell adhesion; endothelial cells; nanotopography; review; platelets; leucocytes; polymer demixing; cell morphology
Subjects: Cellular biophysics; Reviews and tutorial papers; resource letters; Biomedical engineering
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