Computer-controlled piezoactuator for cell manipulation

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Computer-controlled piezoactuator for cell manipulation

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The development of a computer-controlled piezomanipulation system is presented for biomedical applications involving cells manipulation. An application of the developed system to intracytoplasmic sperm injection (ICSI) is presented. The hardware setup and the control strategies are described in full detail to illustrate the advantages of this approach compared to manual injection methods. The system developed offers the automated and efficient execution of the ICSI process, thus achieving an improved success rate in terms of the end objectives of the process.

Inspec keywords: computerised control; piezoelectric actuators; cellular biophysics; medical control systems

Other keywords: manual injection methods; piezoinjection system; end objectives; biomedical applications; control strategies; oocytes structure; piezomicromanipulator; hardware setup; intracytoplasmic sperm injection; computer-controlled piezoactuator; cell manipulation

Subjects: Piezoelectric devices; Cellular biophysics; Biophysical instrumentation and techniques; Biological and medical control systems; Medical physics and biomedical engineering; Microactuators

References

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      • G. Palermo , H. Joris , M.P. Derde , A.C. Van Steirteghem . Pregnancies after intracytoplasmic sperm injection of single spermatozoon into an oocyte. Lancet , 17 - 18
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      • T. Huang , Y. Kimura , R. Yanagimachi . The use of piezo micromanipulation for intracytoplasm sperm injection of human oocytes. J. Assist. Reprod. Genet. , 4 , 320 - 328
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      • T. Nakayama , H. Fujiware , K. Yastumi , K. Fujita , T. Mori . A new assisted hatching technique using a piezo-micromanipulator. Fertil. Steril. , 4 , 784 - 788
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