http://iet.metastore.ingenta.com
1887

Model-based investigation of the transcriptional activity of p53 and its feedback loop regulation via 14-3-3σ

Model-based investigation of the transcriptional activity of p53 and its feedback loop regulation via 14-3-3σ

For access to this article, please select a purchase option:

Buy article PDF
£12.50
(plus tax if applicable)
Buy Knowledge Pack
10 articles for £75.00
(plus taxes if applicable)

IET members benefit from discounts to all IET publications and free access to E&T Magazine. If you are an IET member, log in to your account and the discounts will automatically be applied.

Learn more about IET membership 

Recommend Title Publication to library

You must fill out fields marked with: *

Librarian details
Name:*
Email:*
Your details
Name:*
Email:*
Department:*
Why are you recommending this title?
Select reason:
 
 
 
 
 
IET Systems Biology — Recommend this title to your library

Thank you

Your recommendation has been sent to your librarian.

Experiments have recently shown that p53 expression can display oscillations in response to certain stress signals. In this work, mathematical modelling and bifurcation analysis are combined to investigate under which conditions the oscillation of p53 could propagate to its direct downstream transcription targets. The authors' analysis suggests that oscillations of p53 will propagate only to proteins with medium-fast mRNA and protein turnover rates. The authors retrieved data concerning the half-life of mRNA and protein for a number of p53-promoted genes and found that, according to their model, most of them are not able to inherit the oscillation of p53 because of their slow turnover rates. However, their analysis indicates that p53 oscillation may actually fine-tune the expression pattern of a protein when it is integrated with a second oscillatory signal. The authors also consider the case of additional regulatory loops affecting p53 oscillations and involving proteins transcriptionally induced by p53. Their results for 14-3-3σ, a protein that targets the p53 inhibitor MDM2 for degradation, suggest that the addition of feedback-loop regulation may modulate basic properties of p53 oscillation and induce quick cessation of them under certain physiological conditions. Moreover, the interplay between DNA damage and 14-3-3σ may induce bistability in the oscillation of p53. [Includes supplementary material]

References

    1. 1)
    2. 2)
    3. 3)
    4. 4)
    5. 5)
    6. 6)
    7. 7)
    8. 8)
    9. 9)
    10. 10)
      • Stress-specific response of the p53-Mdm2 feedback loop
    11. 11)
    12. 12)
    13. 13)
    14. 14)
    15. 15)
    16. 16)
    17. 17)
      • mdm2 expression is induced by wild type p53 activity
    18. 18)
    19. 19)
    20. 20)
    21. 21)
    22. 22)
    23. 23)
    24. 24)
    25. 25)
    26. 26)
    27. 27)
    28. 28)
    29. 29)
    30. 30)
    31. 31)
    32. 32)
    33. 33)
      • Estimating of bifurcations and chaotic behaviour in a four-dimensional system
    34. 34)
    35. 35)
      • Behaviour of dynamical systems near the boundary of stability
    36. 36)
      • Theory of Oscillators
    37. 37)
    38. 38)
      • Methods of qualitative theory in nonlinear dynamics
    39. 39)
      • Qualitative theory of differential equations
    40. 40)
    41. 41)
      • Stochastic and chaotic oscillations
    42. 42)
http://iet.metastore.ingenta.com/content/journals/10.1049/iet-syb.2010.0080
Loading

Related content

content/journals/10.1049/iet-syb.2010.0080
pub_keyword,iet_inspecKeyword,pub_concept
6
6
Loading
This is a required field
Please enter a valid email address