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access icon free Nano-encapsulated Tinospora cordifolia (Willd.) using poly (D, L-lactide) nanoparticles educe effective control in streptozotocin-induced type 2 diabetic rats

© The Institution of Engineering and Technology
Received 05/03/2020, Accepted 30/06/2020, Revised 29/05/2020, Published 13/08/2020

The therapeutics for type 2 diabetes mellitus has emerged in the current century towards nanomedicine incorporated with plant active compounds. In this study, Tinospora cordifolia loaded poly (D, L-lactide) (PLA) nanoparticles (NPs) were evaluated in vivo for their anti-hyperglycemic potency towards streptozotocin-induced type 2 diabetic rats. T. cordifolia loaded PLA NPs were synthesised by the double solvent evaporation method using PLA polymer. The NPs were then characterised and administrated orally for 28 successive days to streptozotocin-induced diabetic rats. The PLA NPs had significant anti-diabetic effects which were equal to the existing anti-diabetic drug glibenclamide. The antidiabetic activity is due to the synergism of compounds present in stem extract of the plant which reduced the side effects and anti-diabetic.

Inspec keywords: drug delivery systems; nanomedicine; biomedical materials; blood; drugs; nanofabrication; evaporation; polymers; diseases; nanoparticles; biochemistry

Other keywords: streptozotocin-induced type 2 diabetic rats; diabetic drug glibenclamide; nanoencapsulated Tinospora cordifolia; antidiabetic effects; antihyperglycemic potency; type 2 diabetes mellitus; double-solvent evaporation; nanomedicine; poly(d, l-lactide) nanoparticles; PLA nanoparticles

Subjects: Other methods of nanofabrication; Patient care and treatment; Low-dimensional structures: growth, structure and nonelectronic properties; Biomedical materials; Physical chemistry of biomolecular solutions and condensed states; Nanotechnology applications in biomedicine

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