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access icon free Site-specific delivery of green tea coated aluminium magnesium silicate beads and studies on their effect against chicken coccidiosis

© The Institution of Engineering and Technology
Received 12/02/2020, Accepted 04/05/2020, Revised 10/04/2020, Published 04/05/2020

In this report, the site-specific co-delivery of green tea/aluminium magnesium silicate (AMS) was reported and the specific target delivery was achieved orally. The new co-precipitation process was developed to synthesis the green tea/AMS hybrid complex and using energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy and Raman confirmed its successful synthesis. The blood biocompatibility of the green tea/AMS was tested using chicken blood, and the compound is safe up to 500 mg/ml. After mixed with hydroxypropyl methylcellulose phthalate, the oral beads were synthesised using a linking agent. The oral beads underwent different pH-based dissolution studies and the results indicated that the beads specifically dissolved in gastric pH (6.5). The pharmaco kinetic studies were performed to estimate the delivery kinetics. The results revealed that the beads underwent as per the Higuchi model. The anticoccidial effects of the beads were tested using chicken. The animal studies were performed in two different modes such as prophylactic treatment and active treatment after Eimeria species challenge. The results indicated that the prophylactic treatment with beads 100% protected the chicken and the active treatment with beads after the Eimeria challenge significantly protected against the intestinal damage and it also enhanced the anticoccidial effect.

Inspec keywords: materials preparation; dissolving; drugs; magnesium compounds; Fourier transform infrared spectra; biomedical materials; blood; drug delivery systems; pH; aluminium compounds; X-ray chemical analysis; Raman spectra; precipitation (physical chemistry)

Other keywords: intestinal damage; Eimeria species; chicken coccidiosis; target delivery; green tea coated aluminium magnesium silicate beads; coprecipitation process; anticoccidial effect; blood biocompatibility; pharmacokinetic studies; Raman spectroscopy; prophylactic treatment; Fourier-transform infrared spectroscopy; animal studies; hydroxypropyl methylcellulose phthalate; Higuchi model; site-specific codelivery; oral beads; chicken blood; Al2Mg3O18Si6; anticoccidial effects; gastric pH; energy-dispersive X-ray spectroscopy; active treatment; linking agent; green tea-AMS hybrid complex; pH-based dissolution; delivery kinetics

Subjects: Electrochemistry and electrophoresis; Patient care and treatment; Patient care and treatment; Other methods of preparation of materials; Electromagnetic radiation spectrometry (chemical analysis); Solubility, segregation, and mixing; Infrared and Raman spectra in inorganic crystals; Biomedical materials

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http://iet.metastore.ingenta.com/content/journals/10.1049/iet-nbt.2020.0043
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