In the first section of this research, superparamagnetic nanoparticles (NPs) (Fe₃O₄) modified with hydroxyapatite (HAP) and zirconium oxide (ZrO₂) and thereby Fe₃O₄/HAP and Fe₃O₄/ZrO₂ NPs were synthesised through co-precipitation method. Then Fe₃O₄/HAP and Fe₃O₄/ZrO₂ NPs characterised with various techniques such as X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, Brunauer–Emmett–Teller, Fourier transform infrared, and vibrating sample magnetometer. Observed results confirmed the successful synthesis of desired NPs. In the second section, the antibacterial activity of synthesised magnetic NPs (MNPs) was investigated. This investigation performed with multiple microbial cultivations on the two bacteria; Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Obtained results proved that although both MNPs have good antibacterial properties, however, Fe₃O₄/HAP NP has greater antibacterial performance than the other. Based on minimum inhibitory concentration and minimum bactericidal concentration evaluations, S. aureus bacteria are more sensitive to both NPs. These nanocomposites combine the advantages of MNP and antibacterial effects, with distinctive merits including easy preparation, high inactivation capacity, and easy isolation from sample solutions by the application of an external magnetic field.

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Evaluation of antibacterial property of hydroxyapatite and zirconium oxide-modificated magnetic nanoparticles against Staphylococcus aureus and Escherichia coli

References

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