Your browser does not support JavaScript!
http://iet.metastore.ingenta.com
1887

Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review

Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review

For access to this article, please select a purchase option:

Buy article PDF
$19.95
(plus tax if applicable)
Buy Knowledge Pack
10 articles for $120.00
(plus taxes if applicable)

IET members benefit from discounts to all IET publications and free access to E&T Magazine. If you are an IET member, log in to your account and the discounts will automatically be applied.

Learn more about IET membership 

Recommend Title Publication to library

You must fill out fields marked with: *

Librarian details
Name:*
Email:*
Your details
Name:*
Email:*
Department:*
Why are you recommending this title?
Select reason:
 
 
 
 
 
IET Nanobiotechnology — Recommend this title to your library

Thank you

Your recommendation has been sent to your librarian.

Titanium dioxide (TiO2) has been vastly used commercially, especially as white pigment in paints, colorants, plastics, coatings, cosmetics. Certain industrial uses TiO2 in diameter <100 nm. There are three common exposure routes for TiO2: (i) inhalation exposure, (ii) exposure via gastrointestinal tract, (iii) dermal exposure. Inhalation and gastrointestinal exposure appear to be the most probable ways of exposure, although nanoparticle (NP) penetration is limited. However, the penetration rate may increase substantially when the tissue is impaired. When TiO2 NPs migrate into the circulatory system, they can be distributed into all tissues including brain. In brain, TiO2 lead to oxidative stress mediated by the microglia phagocytic cells which respond to TiO2 NPs by the production and release of superoxide radicals that convert to multiple reactive oxygen species (ROS). The ROS production may also cause the damage of blood–brain barrier which then becomes more permeable for NPs. Moreover, several studies have showed neuron degradation and the impairment of spatial recognition memory and learning abilities in laboratory rodent exposed to TiO2 NPs.

References

    1. 1)
      • 46. Rothen-Rutishauser, B.M., Schurch, S., Haenni, B., et al: ‘Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques’, Environ. Sci. Technol., 2006, 40, (14), pp. 43534359.
    2. 2)
      • 43. Wang, Y., Aker, W.G., Hwang, H.M., et al: ‘A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human Hepg2 cells’, Sci. Total Environ., 2011, 409, (22), pp. 47534762.
    3. 3)
      • 9. Nemmar, A., Hoet, P.H.M., Vanquickenborne, B., et al: ‘Passage of inhaled particles into the blood circulation in humans’, Circulation, 2002, 105, (4), pp. 411414.
    4. 4)
      • 73. Hu, Q., Guo, F., Zhao, F., et al: ‘Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12’, Chemosphere, 2017, 173, pp. 373379.
    5. 5)
      • 11. Geiser, M., Rothen-Rutishauser, B., Kapp, N., et al: ‘Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells’, Environ. Health Perspect., 2005, 113, (11), pp. 15551560.
    6. 6)
      • 59. Ma, L.L., Liu, J., Li, N., et al: ‘Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity’, Biomaterials, 2010, 31, (1), pp. 99105.
    7. 7)
      • 50. Sayes, C.M., Wahi, R., Kurian, P.A., et al: ‘Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells’, Toxicolog. Sci., 2006, 92, (1), pp. 174185.
    8. 8)
      • 49. Gurr, J.R., Wang, A.S., Chen, C.H., et al: ‘Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells’, Toxicology, 2005, 213, (1–2), pp. 6673.
    9. 9)
      • 47. Takeda, K., Suzuki, K.I., Ishihara, A., et al: ‘Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems’, J. Health Sci., 2009, 55, (1), pp. 95102.
    10. 10)
      • 6. Bermudez, E., Mangum, J.B., Asgharian, B., et al: ‘Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles’, Toxicol. Sci., 2002, 70, (1), pp. 8697.
    11. 11)
      • 17. Chen, J.Y., Dong, X., Zhao, J., et al: ‘In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection’, J. Appl. Toxicol., 2009, 29, (4), pp. 330337.
    12. 12)
      • 20. Yah, C.S., Simate, G.S., Iyuke, S.E.: ‘Nanoparticles toxicity and their routes of exposures’, Pak. J. Pharm. Sci., 2012, 25, (2), pp. 477491.
    13. 13)
      • 23. Wang, J., Zhou, G., Chen, C., et al: ‘Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration’, Toxicol. Lett., 2007, 168, (2), pp. 176185.
    14. 14)
      • 31. Lademann, J., Weigmann, H., Rickmeyer, C., et al: ‘Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice’, Skin Pharmacol. Appl. Skin Physiol., 1999, 12, (5), pp. 247256.
    15. 15)
      • 12. Muhlfeld, C., Geiser, M., Kapp, N., et al: ‘Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the ‘relative deposition index’: evidence for clearance through microvasculature’, Part Fibre Toxicol., 2007, 4, p. 7.
    16. 16)
      • 21. Martirosyan, A., Polet, M., Bazes, A., et al: ‘Food nanoparticles and intestinal inflammation: a real risk?’. InTech, 2012, Inflammatory Bowel Disease edition.
    17. 17)
      • 54. Warheit, D.B., Brock, W.J., Lee, K.P., et al: ‘Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity’, Toxicol. Sci., 2005, 88, (2), pp. 514524.
    18. 18)
      • 19. Wang, J., Chen, C., Liu, Y., et al: ‘Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases’, Toxicol. Lett., 2008, 183, (1–3), pp. 7280.
    19. 19)
      • 66. Zhou, Y., Hong, F., Tian, Y., et al: ‘Nanoparticulate titanium dioxide-inhibited dendritic development is involved in apoptosis and autophagy of hippocampal neurons in offspring mice’, Toxicol. Res., 2017, 6, (6), pp. 889901.
    20. 20)
      • 76. Joshi, Y.B., Pratico, D.: ‘Lipid peroxidation in psychiatric illness: overview of clinical evidence’, Oxid. Med. Cell. Longev., 2014, 2014, p. 828702.
    21. 21)
      • 35. Wu, J., Liu, W., Xue, C., et al: ‘Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure’, Toxicol. Lett., 2009, 191, (1), pp. 18.
    22. 22)
      • 1. Popov, A.P., Priezzhev, A.V., Lademann, J., et al: ‘TiO2 nanoparticles as an effective UV-B radiation skin-protective compound in sunscreens’, J. Phys. D Appl. Phys., 2005, 38, (15), pp. 25642570.
    23. 23)
      • 62. Xue, Y., Wu, J., Sun, J.: ‘Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro’, Toxicol. Lett., 2012, 214, (2), pp. 9198.
    24. 24)
      • 30. Tan, M.H., Commens, C.A., Burnett, L., et al: ‘A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens’, Australas J. Dermatol., 1996, 37, (4), pp. 185187.
    25. 25)
      • 14. Li, Y., Li, J., Yin, J., et al: ‘Systematic influence induced by 3 Nm titanium dioxide following intratracheal instillation of mice’, J. Nanosci. Nanotechnol., 2010, 10, (12), pp. 85448549.
    26. 26)
      • 63. Huerta-Garcia, E., Perez-Arizti, J.A., Marquez-Ramirez, S.G., et al: ‘Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells’, Free Radical Biol. Med., 2014, 73, pp. 8494.
    27. 27)
      • 75. Zhao, Y., Zhao, B.: ‘Oxidative stress and the pathogenesis of Alzheimer's disease’, Oxid. Med. Cell. Longev., 2013, 2013, p. 316523.
    28. 28)
      • 70. Shimizu, M., Tainaka, H., Oba, T., et al: ‘Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse’, Part Fibre Toxicol., 2009, 6, 6:20 doi:10.1186/1743-8977-6-20.
    29. 29)
      • 36. Liu, X., Sui, B., Sun, J.: ‘Size-and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood–brain barrier’, J. Mater. Chem. B, 2017, 5, (48), pp. 95589570.
    30. 30)
      • 45. Long, T.C., Saleh, N., Tilton, R.D., et al: ‘Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (Bv2): implications for nanoparticle neurotoxicity’, Environ. Sci. Technol., 2006, 40, (14), pp. 43464352.
    31. 31)
      • 34. Bennat, C., Muller-Goymann, C.C.: ‘Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter’, Int. J. Cosmet. Sci., 2000, 22, (4), pp. 271283.
    32. 32)
      • 71. Mohammadipour, A., Hosseini, M., Fazel, A., et al: ‘The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring’, Toxicol. Ind. Health, 2016, 32, (2), pp. 221228.
    33. 33)
      • 25. MacNicoll, A., Kelly, M., Aksoy, H., et al: ‘A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake’, J. Nanoparticle Res., 2015, 17, (2).
    34. 34)
      • 57. Grissa, I., Guezguez, S., Ezzi, L., et al: ‘The effect of titanium dioxide nanoparticles on neuroinflammation response in rat brain’, Environ. Sci. Pollut. Res., 2016, 23, (20), pp. 2020520213.
    35. 35)
      • 8. Oberdorster, G., Ferin, J., Soderholm, S., et al: ‘Increased pulmonary toxicity of inhaled ultrafine particles - due to lung overload alone’, Inhaled Particles VII, 1994, 38, (1), pp. 295302.
    36. 36)
      • 39. Disdier, C., Chalansonnet, M., Gagnaire, F., et al: ‘Brain inflammation, blood brain barrier dysfunction and neuronal synaptophysin decrease after inhalation exposure to titanium dioxide nano-Aerosol in aging rats’, Sci. Rep., 2017, 7, (1), p. 12196.
    37. 37)
      • 74. Milaneschi, Y., Cesari, M., Simonsick, E.M., et al: ‘Lipid peroxidation and depressed mood in community-dwelling older men and women’, PLoS One, 2013, 8, (6), doi: 10.1371/journal.pone.0065406. Print 2013.
    38. 38)
      • 72. Cui, Y., Chen, X., Zhou, Z., et al: ‘Prenatal exposure to nanoparticulate titanium dioxide enhances depressive-like behaviors in adult rats’, Chemosphere, 2014, 96, pp. 99104.
    39. 39)
      • 28. Powell, J.J., Faria, N., Thomas-McKay, E., et al: ‘Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract’, J. Autoimmunity, 2010, 34, (3), pp. J226J233.
    40. 40)
      • 56. Iavicoli, I., Leso, V., Bergamaschi, A.: ‘Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies’, J. Nanomater., 2012, 2012.
    41. 41)
      • 32. Newman, M.D., Stotland, M., Ellis, J.I.: ‘The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens’, J. Am. Acad. Dermatol., 2009, 61, (4), pp. 685692.
    42. 42)
      • 18. Wang, J., Liu, Y., Jiao, F., et al: ‘Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles’, Toxicology, 2008, 254, (1–2), pp. 8290.
    43. 43)
      • 51. Wang, J.J., Sanderson, B.J., Wang, H.: ‘Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells’, Mutat. Res., 2007, 628, (2), pp. 99106.
    44. 44)
      • 60. Umezawa, M., Tainaka, H., Kawashima, N., et al: ‘Effect of fetal exposure to titanium dioxide nanoparticle on brain development– brain region information’, J. Toxicol. Sci., 2012, 37, (6), pp. 12471252.
    45. 45)
      • 67. Shin, J.A., Lee, E.J., Seo, S.M., et al: ‘Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse’, Neuroscience, 2010, 165, (2), pp. 445454.
    46. 46)
      • 37. Brun, E., Carriere, M., Mabondzo, A.: ‘In vitro evidence of dysregulation of blood-brain barrier function after acute and repeated/long-term exposure to TiO2 nanoparticles’, Biomaterials, 2012, 33, (3), pp. 886896.
    47. 47)
      • 13. Geiser, M.: ‘Update on macrophage clearance of inhaled micro- and nanoparticles’, J. Aerosol. Med. Pulm. Drug Deliv., 2010, 23, (4), pp. 207217.
    48. 48)
      • 55. Kwon, S., Yang, Y.S., Yang, H.S., et al: ‘Nasal and pulmonary toxicity of titanium dioxide nanoparticles in rats’, Toxicol. Res., 2012, 28, (4), pp. 217224.
    49. 49)
      • 68. Hsiao, I.L., Chang, C.C., Wu, C.Y.: ‘Indirect effects of TiO2 nanoparticle on neuron-glial cell interactions’, Chemico-Biolog. Interact., 2016, 254, pp. 3444.
    50. 50)
      • 61. Block, M.L., Zecca, L., Hong, J.S.: ‘Microglia-mediated neurotoxicity: uncovering the molecular mechanisms’, Nat. Rev. Neurosci., 2007, 8, (1), pp. 5769.
    51. 51)
      • 7. Bermudez, E., Mangum, J.B., Wong, B.A., et al: ‘Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles’, Toxicol. Sci., 2004, 77, (2), pp. 347357.
    52. 52)
      • 58. Jia, X., Wang, S., Zhou, L., et al: ‘The potential liver, brain, and embryo toxicity of titanium dioxide nanoparticles on mice’, Nanoscale Res. Lett., 2017, 12, (1), p. 478.
    53. 53)
      • 29. Senzui, M., Tamura, T., Miura, K., et al: ‘Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro’, J. Toxicol. Sci., 2010, 35, (1), pp. 107113.
    54. 54)
      • 42. Halamoda Kenzaoui, B., Chapuis Bernasconi, C., Guney-Ayra, S., et al: ‘Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells’, Biochem. J., 2012, 441, (3), pp. 813821.
    55. 55)
      • 65. Irie, T., Kawakami, T., Sato, K., et al: ‘Sub-toxic concentrations of nano-ZnO and nano-TiO2 suppress neurite outgrowth in differentiated PC12 cells’, J. Toxicolog. Sci., 2017, 42, (6), pp. 723729.
    56. 56)
      • 48. Afaq, F., Abidi, P., Matin, R., et al: ‘Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide’, J. Appl. Toxicol., 1998, 18, (5), pp. 307312.
    57. 57)
      • 10. Wiebert, P., Sanchez-Crespo, A., Seitz, J., et al: ‘Negligible clearance of ultrafine particles retained in healthy and affected human lungs’, Eur. Respir. J., 2006, 28, (2), pp. 286290.
    58. 58)
      • 16. Liu, H., Ma, L., Zhao, J., et al: ‘Biochemical toxicity of nano-anatase TiO2 particles in mice’, Biol. Trace Elem. Res., 2009, 129, (1–3), pp. 170180.
    59. 59)
      • 5. Yu, K.N., Sung, J.H., Lee, S., et al: ‘Inhalation of titanium dioxide induces endoplasmic reticulum stress-mediated autophagy and inflammation in mice’, Food Chem. Toxicol., 2015, 85, pp. 106113.
    60. 60)
      • 38. Chen, I.C., Hsiao, I.L., Lin, H.C., et al: ‘Influence of silver and titanium dioxide nanoparticles on in vitro blood-brain barrier permeability’, Environ. Toxicol. Pharmacol., 2016, 47, pp. 108118.
    61. 61)
      • 69. Mohamed, H.R., Hussien, N.A.: ‘Genotoxicity studies of titanium dioxide nanoparticles (TiO2NPs) in the brain of mice’, Scientifica, 2016.
    62. 62)
      • 44. Long, T.C., Tajuba, J., Sama, P., et al: ‘Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro’, Environ. Health Perspect., 2007, 115, (11), pp. 16311637.
    63. 63)
      • 52. Zhang, Y., Yu, W., Jiang, X., et al: ‘Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine Mc3t3-E1 preosteoblasts’, J. Mater. Sci. Mater. Med., 2011, 22, (8), pp. 19331945.
    64. 64)
      • 4. Grassian, V.H., O'Shaughnessy, P.T., Adamcakova-Dodd, A., et al: ‘Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 Nm’, Environ. Health Perspect., 2007, 115, (3), pp. 397402.
    65. 65)
      • 24. Janer, G., Mas del Molino, E., Fernandez-Rosas, E., et al: ‘Cell uptake and oral absorption of titanium dioxide nanoparticles’, Toxicol. Lett., 2014, 228, (2), pp. 103110.
    66. 66)
      • 40. Allouni, Z.E., Hol, P.J., Cauqui, M.A., et al: ‘Role of physicochemical characteristics in the uptake of TiO2 nanoparticles by fibroblasts’, Toxicol. In Vitro, 2012, 26, (3), pp. 469479.
    67. 67)
      • 33. Sadrieh, N., Wokovich, A.M., Gopee, N.V., et al: ‘Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles’, Toxicol. Sci., 2010, 115, (1), pp. 156166.
    68. 68)
      • 3. Kreyling, W.G., Semmler-Behnke, M., Takenaka, S., et al: ‘Differences in the biokinetics of inhaled nano- versus micrometer-sized particles’, Acc. Chem. Res., 2013, 46, (3), pp. 714722.
    69. 69)
      • 15. Eydner, M., Schaudien, D., Creutzenberg, O., et al: ‘Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes, translocation within the rat lung, and evaluation of particle deposition using the relative deposition index’, Inhal. Toxicol., 2012, 24, (9), pp. 557569.
    70. 70)
      • 27. Mohammadipour, A., Fazel, A., Haghir, H., et al: ‘Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring’, Environ. Toxicol. Pharmacol., 2014, 37, (2), pp. 617625.
    71. 71)
      • 64. Hu, R.P., Gong, X.L., Duan, Y.M., et al: ‘Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles’, Biomaterials, 2010, 31, (31), pp. 80438050.
    72. 72)
      • 41. Andersson-Willman, B., Gehrmann, U., Cansu, Z., et al: ‘Effects of subtoxic concentrations of TiO2 and Zno nanoparticles on human lymphocytes, dendritic cells and exosome production’, Toxicol. Appl. Pharmacol., 2012, 264, (1), pp. 94103.
    73. 73)
      • 22. Jani, P.U., McCarthy, D.E., Florence, A.T.: ‘Titanium dioxide (rutile) particle uptake from the Rat Gi tract and translocation to systemic organs after oral administration’, Int. J. Pharm., 1994, 105, (2), pp. 157168.
    74. 74)
      • 53. Lee, K.P., Trochimowicz, H.J., Reinhardt, C.F.: ‘Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years’, Toxicol. Appl. Pharmacol., 1985, 79, (2), pp. 179192.
    75. 75)
      • 26. Tassinari, R., Cubadda, F., Moracci, G., et al: ‘Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen’, Nanotoxicology, 2014, 8, (6), pp. 654662.
    76. 76)
      • 2. Shah, S.N.A., Shah, Z., Hussain, M., et al: ‘Hazardous effects of titanium dioxide nanoparticles in ecosystem’, Bioinorganic Chem. Appl., 2017, 4101735.
http://iet.metastore.ingenta.com/content/journals/10.1049/iet-nbt.2017.0109
Loading

Related content

content/journals/10.1049/iet-nbt.2017.0109
pub_keyword,iet_inspecKeyword,pub_concept
6
6
Loading
This is a required field
Please enter a valid email address