Synthesis, characterisation and potential biomedical applications of magnetic core–shell structures: carbon-, dextran-, SiO2- and ZnO-coated Fe3O4 nanoparticles
- Author(s): Komail Boustani 1 ; Saber Farjami Shayesteh 2 ; Mojtaba Salouti 3 ; Atefeh Jafari 2 ; Alireza Ahadpour Shal 4
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View affiliations
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Affiliations:
1:
Department of Physics , Payame Noor University , Tehran , Iran ;
2: Nanostructure Lab , Physics Department , University of Guilan , Rasht , Iran ;
3: Department of Microbiology, Faculty of Sciences, Zanjan Branch , Islamic Azad University , Zanjan , Iran ;
4: Department of Electrical Engineering , Faculty of Engineering , Islamic Azad University , Lahijan Branch , Lahijan , Iran
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Affiliations:
1:
Department of Physics , Payame Noor University , Tehran , Iran ;
- Source:
Volume 12, Issue 1,
February
2018,
p.
78 – 86
DOI: 10.1049/iet-nbt.2017.0044 , Print ISSN 1751-8741, Online ISSN 1751-875X
Due to the strong effect of nanoparticles' size and surface properties on cellular uptake and bio-distribution, the selection of coating material for magnetic core–shell nanoparticles (CSNPs) is very important. In this study, the effects of four different biocompatible coating materials on the physical properties of Fe3O4 (magnetite) nanoparticles (NPs) for different biomedical applications are investigated and compared. In this regard, magnetite NPs are prepared by a simple co-precipitation method. Then, CSNPs including Fe3O4 as a core and carbon, dextran, ZnO (zincite) and SiO2 (silica) as different shells are synthesised using simple one- or two-step methods. A comprehensive study is carried out on the prepared samples using X-ray diffraction, vibrating sample magnetometry, transmission electron microscopy and Fourier transform infrared spectroscopy analyses. According to the authors' findings, it is suggested that carbon- and dextran-coated magnetite NPs with high M s have great potential in the application of magnetic resonance imaging contrast agents. Moreover, silica-coated magnetite NPs with high coercivity are potentially suitable candidates for hyperthermia and ZnO-coated Fe3O4 is potentially suitable for photothermal therapy.
Inspec keywords: silicon compounds; infrared spectra; magnetic particles; nanofabrication; X-ray diffraction; Fourier transform spectra; nanoparticles; radiation therapy; magnetometry; transmission electron microscopy; iron compounds; nanomedicine; zinc compounds; biomedical materials; coatings; carbon; biomedical MRI; hyperthermia
Other keywords: CSNP; zincite; dextran; transmission electron microscopy; vibrating sample magnetometry; biodistribution; ZnO-Fe3O4; hyperthermia; coating material; SiO2-Fe3O4; silica; co-precipitation; biocompatible coating materials; magnetic core-shell nanoparticles; cellular uptake; X-ray diffraction; Fourier transform infrared spectroscopy; biomedical applications; magnetic resonance imaging contrast agents; photothermal therapy
Subjects: Biomedical materials; Fine-particle magnetic systems; Methods of nanofabrication and processing; Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Optical properties of other inorganic semiconductors and insulators (thin films, low-dimensional and nanoscale structures); Nanotechnology applications in biomedicine; Infrared and Raman spectra and scattering (condensed matter)
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