Synthesis, characterisation and potential biomedical applications of magnetic core–shell structures: carbon-, dextran-, SiO2- and ZnO-coated Fe3O4 nanoparticles

Komail Boustani; Saber Farjami Shayesteh; Mojtaba Salouti; Atefeh Jafari; Alireza Ahadpour Shal

Synthesis, characterisation and potential biomedical applications of magnetic core–shell structures: carbon-, dextran-, SiO₂- and ZnO-coated Fe₃O₄ nanoparticles

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Author(s): Komail Boustani¹ ; Saber Farjami Shayesteh² ; Mojtaba Salouti³ ; Atefeh Jafari² ; Alireza Ahadpour Shal⁴
- Affiliations: 1: Department of Physics , Payame Noor University , Tehran , Iran ;
  2: Nanostructure Lab , Physics Department , University of Guilan , Rasht , Iran ;
  3: Department of Microbiology, Faculty of Sciences, Zanjan Branch , Islamic Azad University , Zanjan , Iran ;
  4: Department of Electrical Engineering , Faculty of Engineering , Islamic Azad University , Lahijan Branch , Lahijan , Iran
Source: Volume 12, Issue 1, February 2018, p. 78 – 86
DOI: 10.1049/iet-nbt.2017.0044 , Print ISSN 1751-8741, Online ISSN 1751-875X

Received 07/03/2017, Accepted 28/09/2017, Revised 28/08/2017, Published 01/11/2017

Due to the strong effect of nanoparticles' size and surface properties on cellular uptake and bio-distribution, the selection of coating material for magnetic core–shell nanoparticles (CSNPs) is very important. In this study, the effects of four different biocompatible coating materials on the physical properties of Fe₃O₄ (magnetite) nanoparticles (NPs) for different biomedical applications are investigated and compared. In this regard, magnetite NPs are prepared by a simple co-precipitation method. Then, CSNPs including Fe₃O₄ as a core and carbon, dextran, ZnO (zincite) and SiO₂ (silica) as different shells are synthesised using simple one- or two-step methods. A comprehensive study is carried out on the prepared samples using X-ray diffraction, vibrating sample magnetometry, transmission electron microscopy and Fourier transform infrared spectroscopy analyses. According to the authors' findings, it is suggested that carbon- and dextran-coated magnetite NPs with high M _s have great potential in the application of magnetic resonance imaging contrast agents. Moreover, silica-coated magnetite NPs with high coercivity are potentially suitable candidates for hyperthermia and ZnO-coated Fe₃O₄ is potentially suitable for photothermal therapy.

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Synthesis, characterisation and potential biomedical applications of magnetic core–shell structures: carbon-, dextran-, SiO₂- and ZnO-coated Fe₃O₄ nanoparticles

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