Low noise patch-clamp current amplification by nanoparticles plasmonic–photonic coupling (analysis and modelling)

E. O. Haberal; A. SalmanOgli; B. Nasseri

Low noise patch-clamp current amplification by nanoparticles plasmonic–photonic coupling (analysis and modelling)

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Author(s): E. O. Haberal ¹ ; A. SalmanOgli ² ; B. Nasseri ³
- Affiliations: 1: Baskent University, Department of Biomedical Engineering, 06800, Ankara, Angora, Turkey ;
  2: Electrical Engineering Department, Tabriz University, 51666, Tabriz, Iran ;
  3: Hacettepe University, Chemical Engineering Department, Bioengineering Division, 06800, Ankara, Turkey
Source: Volume 10, Issue 5, October 2016, p. 315 – 320
DOI: 10.1049/iet-nbt.2015.0066 , Print ISSN 1751-8741, Online ISSN 1751-875X

Received 13/09/2015, Accepted 07/03/2016, Revised 08/01/2016, Published 01/10/2016

In this article, a patch-clamp low noise current amplification based on nanoparticles plasmonic radiation is analyzed. It is well-known, a very small current is flowing from different membrane channels and so, for extra processing the current amplification is necessary. It is notable that there are some problems in traditional electronic amplifier due to its noise and bandwidth problem. Because of the important role of the patch-clamp current in cancer research and especially its small amplitude, it is vital to intensify it without adding any noises. In this study, the current amplification is performed firstly: from the excitement of nanoparticles by the patch-clamp pico-ampere current and then, the effect of nanoparticles plasmonic far-field radiation on conductor's carriers, which will cause the current amplification. This relates to the plasmonic-photonic coupling and their effect on conductor carriers as the current perturbation agent. In the steady state, the current amplification can reach to 1000 times of initial level. Furthermore, we investigated the nanoparticles morphology changing effect such as size, nanoparticles inter-distance, and nanoparticles distance from the conductor on the amplifier parameters. Finally, it should note that the original aim is to use nanoparticles plasmonic engineering and their coupling to photonics for output current manipulating.

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Low noise patch-clamp current amplification by nanoparticles plasmonic–photonic coupling (analysis and modelling)

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