Nanobiotechnology and its applications in drug delivery system: a review

Imran Khan; Momin Khan; Muhammad Naveed Umar; Deog-Hwan Oh

Nanobiotechnology and its applications in drug delivery system: a review

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Author(s): Imran Khan ^{1, 2} ; Momin Khan ² ; Muhammad Naveed Umar ³ ; Deog-Hwan Oh ¹
- Affiliations: 1: Department of Food Science and Biotechnology, School of Bio-convergence Science and Technology, Kangwon National University, Chuncheon, Gangwon 200–701, Republic of Korea ;
  2: Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan ;
  3: Department of Chemistry, University of Malakand, Chakdara 23800, Pakistan
Source: Volume 9, Issue 6, December 2015, p. 396 – 400
DOI: 10.1049/iet-nbt.2014.0062 , Print ISSN 1751-8741, Online ISSN 1751-875X

Received 02/10/2014, Accepted 03/06/2015, Revised 12/05/2015, Published 01/12/2015

Nanobiotechnology holds great potential in various regimes of life sciences. In this review, the potential applications of nanobiotechnology in various sectors of nanotechnologies, including nanomedicine and nanobiopharmaceuticals, are highlighted. To overcome the problems associated with drug delivery, nanotechnology has gained increasing interest in recent years. Nanosystems with different biological properties and compositions have been extensively investigated for drug delivery applications. Nanoparticles fabricated through various techniques have elevated therapeutic efficacy, provided stability to the drugs and proved capable of targeting the cells and controlled release inside the cell. Polymeric nanoparticles have shown increased development and usage in drug delivery as well as in diagnostics in recent decades.

References

1. 1)
  - 9. Xia, Y., Xiong, Y., Lim, B., Skrabalak, S.E.: ‘Shape-controlled synthesis of metal nanocrystals: simple chemistry meets complex physics?’, Angew. Chem. Int. Ed., 2009, 48, (1), pp. 60–103 (doi: 10.1002/anie.200802248).
2. 2)
  - 46. Cammas-Marion, S., Okano, T., Kataoka, K.: ‘Functional and site-specific macromolecular micelles as high potential drug carriers’, Colloids Surf. B Biointerfaces, 1999, 16, (1), pp. 207–215 (doi: 10.1016/S0927-7765(99)00071-5).
3. 3)
  - 58. Patel, M., Shah, T., Amin, A.: ‘Therapeutic opportunities in colon-specific drug-delivery systems’, Crit. Rev. Ther. Drug Carrier Syst., 2007, 24, (2), pp. 147–202 (doi: 10.1615/CritRevTherDrugCarrierSyst.v24.i2.20).
4. 4)
  - 68. Schneider, T., Sachse, A., Leike, J., et al: ‘Surface modification of continuously extruded contrast-carrying liposomes: effect on their physical properties’, Int. J. Pharm., 1996, 132, (1), pp. 9–21 (doi: 10.1016/0378-5173(95)04247-4).
5. 5)
  - 41. Papahadjopoulos, D., Gabizon, A.: ‘Liposomes designed to avoid the reticuloendothelial system’, Prog. Clin. Biol. Res., 1989, 343, pp. 85–93.
6. 6)
  - 17. Chan, W.C., Maxwell, D.J., Gao, X., Bailey, R.E., Han, M., Nie, S.: ‘Luminescent quantum dots for multiplexed biological detection and imaging’, Curr. Opin. Biotechnol., 2002, 13, (1), pp. 40–46 (doi: 10.1016/S0958-1669(02)00282-3).
7. 7)
  - 59. Min, K.H., Park, K., Kim, Y.-S., et al: ‘Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy’, J. Control. Release, 2008, 127, (3), pp. 208–218 (doi: 10.1016/j.jconrel.2008.01.013).
8. 8)
  - 55. Cai, S., Vijayan, K., Cheng, D., Lima, E.M., Discher, D.E.: ‘Micelles of different morphologies – advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery’, Pharm. Res., 2007, 24, (11), pp. 2099–2109.
9. 9)
  - 49. Dalhaimer, P., Bates, F.S., Aranda-Espinoza, H., Discher, D.: ‘Synthetic cell elements from block copolymers – hydrodynamic aspects’, Comptes Rendus Phys., 2003, 4, (2), pp. 251–258 (doi: 10.1016/S1631-0705(03)00028-8).
10. 10)
  - 44. Yamazaki, N., Kojima, S., Yokoyama, H.: ‘Biomedical nanotechnology for active drug delivery systems by applying sugar-chain molecular functions’, Curr. Appl. Phys., 2005, 5, (2), pp. 112–117 (doi: 10.1016/j.cap.2004.06.017).
11. 11)
  - 48. Kabanov, A.V., Batrakova, E.V., Melik-Nubarov, N.S., et al: ‘A new class of drug carriers: micelles of poly (oxyethylene)-poly (oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain’, J. Control. Release, 1992, 22, (2), pp. 141–157 (doi: 10.1016/0168-3659(92)90199-2).
12. 12)
  - 10. Peer, D., Karp, J.M., Hong, S., Farokhzad, O.C., Margalit, R., Langer, R.: ‘Nanocarriers as an emerging platform for cancer therapy’, Nat. Nanotechnol., 2007, 2, (12), pp. 751–760 (doi: 10.1038/nnano.2007.387).
13. 13)
  - 66. Roldo, M., Hornof, M., Caliceti, P., Bernkop-Schnürch, A.: ‘Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation’, Eur. J. Pharm. Biopharm., 2004, 57, (1), pp. 115–121 (doi: 10.1016/S0939-6411(03)00157-7).
14. 14)
  - 19. Larson, D.R., Zipfel, W.R., Williams, R.M., et al: ‘Water-soluble quantum dots for multiphoton fluorescence imaging in vivo’, Science, 2003, 300, (5624), pp. 1434–1436 (doi: 10.1126/science.1083780).
15. 15)
  - 1. Sahoo, S.K., Parveen, S., Panda, J.J.: ‘The present and future of nanotechnology in human health care’, Nanomed. Nanotechnol. Biol. Med., 2007, 1, pp. 20–31 (doi: 10.1016/j.nano.2006.11.008).
16. 16)
  - 51. Bermudez, H., Brannan, A.K., Hammer, D.A., Bates, F.S., Discher, D.E.: ‘Molecular weight dependence of polymersome membrane structure, elasticity, and stability’, Macromolecules, 2002, 35, (21), pp. 8203–8208 (doi: 10.1021/ma020669l).
17. 17)
  - 7. Na, K., Bae, Y.: ‘Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate: characterization, aggregation, and adriamycin release in vitro’, Pharm. Res., 2002, 19, (5), pp. 681–688 (doi: 10.1023/A:1015370532543).
18. 18)
  - 22. O'Brien, T.P., Bult, C.J., Cremer, C., et al: ‘Genome function and nuclear architecture: from gene expression to nanoscience’, Genome Res., 2003, 13, (6a), pp. 1029–1041 (doi: 10.1101/gr.946403).
19. 19)
  - 42. Lin, H.-Y., Thomas, J.L.: ‘PEG-lipids and oligo (ethylene glycol) surfactants enhance the ultrasonic permeabilizability of liposomes’, Langmuir, 2003, 19, (4), pp. 1098–1105 (doi: 10.1021/la026604t).
20. 20)
  - 36. Fielding, R.M.: ‘Liposomal drug delivery’, Clin. Pharmacokinet., 1991, 21, (3), pp. 155–164.
21. 21)
  - 64. Kast, C.E., Valenta, C., Leopold, M., Bernkop-Schnürch, A.: ‘Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole’, J. Control. Release, 2002, 81, (3), pp. 347–354 (doi: 10.1016/S0168-3659(02)00077-9).
22. 22)
  - 29. Raveh, A., Zukerman, I., Shneck, R., Avni, R., Fried, I.: ‘Thermal stability of nanostructured superhard coatings: a review’, Surf. Coat. Technol., 2007, 201, (13), pp. 6136–6142 (doi: 10.1016/j.surfcoat.2006.08.131).
23. 23)
  - 37. Lasic, D.D., Papahadjopoulos, D.: ‘Medical applications of liposomes’ (Elsevier, 1998).
24. 24)
  - 69. Hayward, R.C., Utada, A.S., Dan, N., Weitz, D.A.: ‘Dewetting instability during the formation of polymersomes from block-copolymer-stabilized double emulsions’, Langmuir, 2006, 22, (10), pp. 4457–4461 (doi: 10.1021/la060094b).
25. 25)
  - 4. Sahoo, S.K., Labhasetwar, V.: ‘Nanotech approaches to drug delivery and imaging’, Drug Discov. Today, 2003, 8, (24), pp. 1112–1120 (doi: 10.1016/S1359-6446(03)02903-9).
26. 26)
  - 50. Dalhaimer, P., Engler, A.J., Parthasarathy, R., Discher, D.E.: ‘Targeted worm micelles’, Biomacromolecules, 2004, 5, (5), pp. 1714–1719 (doi: 10.1021/bm049884v).
27. 27)
  - 62. Hornof, M.D., Kast, C.E., Bernkop-Schnürch, A.: ‘In vitro evaluation of the viscoelastic properties of chitosan–thioglycolic acid conjugates’, Eur. J. Pharm. Biopharm., 2003, 55, (2), pp. 185–190 (doi: 10.1016/S0939-6411(02)00162-5).
28. 28)
  - 6. Crommelin, D.J., Storm, G., Jiskoot, W., Stenekes, R., Mastrobattista, E., Hennink, W.E.: ‘Nanotechnological approaches for the delivery of macromolecules’, J. Control. Release, 2003, 87, (1), pp. 81–88 (doi: 10.1016/S0168-3659(03)00014-2).
29. 29)
  - 47. Lavasanifar, A., Samuel, J., Kwon, G.S.: ‘Poly (ethylene oxide)-block-poly (l-amino acid) micelles for drug delivery’, Adv. Drug Deliv. Rev., 2002, 54, (2), pp. 169–190 (doi: 10.1016/S0169-409X(02)00015-7).
30. 30)
  - 6. Parveen, S., Misra, R., Sahoo, S.-K.: ‘Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging’, Nanomedicine: NBM, 2012, 8, pp. 147–166 (doi: 10.1016/j.nano.2011.05.016).
31. 31)
  - 13. Jaffer, F.A., Weissleder, R.: ‘Seeing within molecular imaging of the cardiovascular system’, Circ. Res., 2004, 94, (4), pp. 433–445 (doi: 10.1161/01.RES.0000119321.18573.5A).
32. 32)
  - 38. Sapra, P., Allen, T.: ‘Ligand-targeted liposomal anticancer drugs’, Prog. Lipid Res., 2003, 42, (5), pp. 439–462 (doi: 10.1016/S0163-7827(03)00032-8).
33. 33)
  - 18. Jaiswal, J.K., Mattoussi, H., Mauro, J.M., Simon, S.M.: ‘Long-term multiple color imaging of live cells using quantum dot bioconjugates’, Nat. Biotechnol., 2003, 21, (1), pp. 47–51 (doi: 10.1038/nbt767).
34. 34)
  - 24. Trouiller, P., Olliaro, P., Torreele, E., Orbinski, J., Laing, R., Ford, N.: ‘Drug development for neglected diseases: a deficient market and a public-health policy failure’, Lancet, 2002, 359, (9324), pp. 2188–2194 (doi: 10.1016/S0140-6736(02)09096-7).
35. 35)
  - 33. Dong, Y., Feng, S.-S.: ‘Methoxy poly (ethylene glycol)-poly (lactide)(MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs’, Biomaterials, 2004, 25, (14), pp. 2843–2849 (doi: 10.1016/j.biomaterials.2003.09.055).
36. 36)
  - 20. Moghimi, S.M., Hunter, A.C., Murray, J.C.: ‘Nanomedicine: current status and future prospects’, FASEB J., 2005, 19, (3), pp. 311–330 (doi: 10.1096/fj.04-2747rev).
37. 37)
  - 16. Watson, A., Wu, X., Bruchez, M.: ‘Lighting up cells with quantum dots’, Biotechniques, 2003, 34, (2), p. 296.
38. 38)
  - 23. Buzea, C., Pacheco, I.I., Robbie, K.: ‘Nanomaterials and nanoparticles: sources and toxicity’, Biointerphases, 2007, 2, (4), pp. MR17–MR71 (doi: 10.1116/1.2815690).
39. 39)
  - 27. Varshney, R., Bhadauria, S., Gaur, M.S.: ‘A review: biological synthesis of silver and copper nanoparticles’, Nano Biomed. Eng., 2012, 4, (2), pp. 99–106 (doi: 10.5101/nbe.v4i2.p99-106).
40. 40)
  - 1. Roco, M.C.: ‘Nanotechnology: convergence with modern biology and medicine’, Curr. Opin. Biotechnol., 2003, 14, (3), pp. 337–346 (doi: 10.1016/S0958-1669(03)00068-5).
41. 41)
  - 39. Allen, T., Chonn, A.: ‘Large unilamellar liposomes with low uptake into the reticuloendothelial system’, FEBS Lett., 1987, 223, (1), pp. 42–46 (doi: 10.1016/0014-5793(87)80506-9).
42. 42)
  - 26. Miller, C., Waller, E., Klingemann, H., et al: ‘Lipid formulations of amphotericin B preserve and stabilize renal function in HSCT recipients’, Bone Marrow Transplant., 2004, 33, (5), pp. 543–548 (doi: 10.1038/sj.bmt.1704408).
43. 43)
  - 53. Gao, Z., Oh, K., Kim, C.-K.: ‘Preparation and characterization of sustained-release microspheres of chlorpromazine’, J. Microencapsul., 1998, 15, (1), pp. 75–83 (doi: 10.3109/02652049809006837).
44. 44)
  - 52. Arap, W., Pasqualini, R., Ruoslahti, E.: ‘Chemotherapy targeted to tumor vasculature’, Curr. Opin. Oncol., 1998, 10, (6), pp. 560–565 (doi: 10.1097/00001622-199811000-00014).
45. 45)
  - 12. Tyagi, S., Kramer, F.R.: ‘Molecular beacons: probes that fluoresce upon hybridization’, Nat. Biotechnol., 1996, 14, (3), pp. 303–308 (doi: 10.1038/nbt0396-303).
46. 46)
  - 45. Kwon, G.S., Kataoka, K.: ‘Block copolymer micelles as long-circulating drug vehicles’, Adv. Drug Deliv. Rev., 1995, 16, (2), pp. 295–309 (doi: 10.1016/0169-409X(95)00031-2).
47. 47)
  - 57. Vinogradov, S.V., Bronich, T.K., Kabanov, A.V.: ‘Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells’, Adv. Drug Deliv. Rev., 2002, 54, (1), pp. 135–147 (doi: 10.1016/S0169-409X(01)00245-9).
48. 48)
  - 14. Perez, J.M., Josephson, L., Weissleder, R.: ‘Use of magnetic nanoparticles as nanosensors to probe for molecular interactions’, Chem. Biol. Chem., 2004, 5, (3), pp. 261–264 (doi: 10.1002/cbic.200300730).
49. 49)
  - 31. Govender, T., Stolnik, S., Garnett, M.C., Illum, L., Davis, S.S.: ‘PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug’, J. Control. Release, 1999, 57, (2), pp. 171–185 (doi: 10.1016/S0168-3659(98)00116-3).
50. 50)
  - 15. Saleh, A., Schroeter, M., Jonkmanns, C., Hartung, H.P., Mödder, U., Jander, S.: ‘In vivo MRI of brain inflammation in human ischaemic stroke’, Brain, 2004, 127, (7), pp. 1670–1677 (doi: 10.1093/brain/awh191).
51. 51)
  - 35. Morones, J.R., Elechiguerra, J.L., Camacho, A., et al: ‘The bactericidal effect of silver nanoparticles’, Nanotechnology, 2005, 16, (10), pp. 2346–2353 (doi: 10.1088/0957-4484/16/10/059).
52. 52)
  - 54. Discher, B.M., Won, Y.-Y., Ege, D.S., et al: ‘Polymersomes: tough vesicles made from diblock copolymers’, Science, 1999, 284, (5417), pp. 1143–1146 (doi: 10.1126/science.284.5417.1143).
53. 53)
  - 43. Allen, T., Hansen, C.: ‘Pharmacokinetics of stealth versus conventional liposomes: effect of dose’, Biochim. Biophys. Acta (BBA)-Biomembr., 1991, 1068, (2), pp. 133–141 (doi: 10.1016/0005-2736(91)90201-I).
54. 54)
  - 11. Kim, B.Y., Rutka, J.T., Chan, W.C.: ‘Nanomedicine’, N. Engl. J. Med., 2010, 363, (25), pp. 2434–2443 (doi: 10.1056/NEJMra0912273).
55. 55)
  - 8. Couvreur, P., Barratt, G., Fattal, E., Legrand, P., Vauthier, C.: ‘Nanocapsule technology: a review’, Crit. Rev. Ther. Drug Carrier Syst., 2002, 19, (2), pp. 99–134 (doi: 10.1615/CritRevTherDrugCarrierSyst.v19.i2.10).
56. 56)
  - 25. Allen, T.M., Cullis, P.R.: ‘Drug delivery systems: entering the mainstream’, Science, 2004, 303, (5665), pp. 1818–1822 (doi: 10.1126/science.1095833).
57. 57)
  - 60. Sharma, S., Kulkarni, J., Pawar, A.: ‘Permeation enhancers in the transmucosal delivery of macromolecules’, Pharmazie, Int. J. Pharm. Sci., 2006, 61, (6), pp. 495–504.
58. 58)
  - 2. Ernest, H., Shetty, R.: ‘Impact of nanotechnology on biomedical sciences: review of current concepts on convergence of nanotechnology with biology’, J. Nanotechnol. Online, 2005, 1, pp. 1–14.
59. 59)
  - 32. Fonseca, C., Simoes, S., Gaspar, R.: ‘Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity’, J. Control. Release, 2002, 83, (2), pp. 273–286 (doi: 10.1016/S0168-3659(02)00212-2).
60. 60)
  - 56. Pata, V., Dan, N.: ‘The effect of chain length on protein solubilization in polymer-based vesicles (polymersomes)’, Biophys. J., 2003, 85, (4), pp. 2111–2118 (doi: 10.1016/S0006-3495(03)74639-6).
61. 61)
  - 67. Luo, Y., Zhang, B., Cheng, W.-H., Wang, Q.: ‘Preparation, characterization and evaluation of selenite-loaded chitosan/TPP nanoparticles with or without zein coating’, Carbohydrate Polymers, 2010, 82, (3), pp. 942–951 (doi: 10.1016/j.carbpol.2010.06.029).
62. 62)
  - 61. Rodrigues, S., Dionísio, M., López, C.R., Grenha, A.: ‘Biocompatibility of chitosan carriers with application in drug delivery’, J. Funct. Biomater., 2012, 3, (3), pp. 615–641 (doi: 10.3390/jfb3030615).
63. 63)
  - 40. Gabizon, A., Papahadjopoulos, D.: ‘Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors’, Proc. Natl. Acad. Sci., 1988, 85, (18), pp. 6949–6953 (doi: 10.1073/pnas.85.18.6949).
64. 64)
  - 34. Zhang, X., Li, Y., Chen, X., et al: ‘Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate’, Biomaterials, 2005, 26, (14), pp. 2121–2128 (doi: 10.1016/j.biomaterials.2004.06.024).
65. 65)
  - 5. Brigger, I., Dubernet, C., Couvreur, P.: ‘Nanoparticles in cancer therapy and diagnosis’, Adv. Drug Deliv. Rev., 2002, 54, (5), pp. 631–651 (doi: 10.1016/S0169-409X(02)00044-3).
66. 66)
  - 21. Rolland, J.P., Maynor, B.W., Euliss, L.E., Exner, A.E., Denison, G.M., DeSimone, J.M.: ‘Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials’, J. Am. Chem. Soc., 2005, 127, (28), pp. 10096–10100 (doi: 10.1021/ja051977c).
67. 67)
  - 63. Moghaddam, F.A., Atyabi, F., Dinarvand, R.: ‘Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles’, Nanomed. Nanotechnol. Biol. Med., 2009, 5, (2), pp. 208–215 (doi: 10.1016/j.nano.2008.09.006).
68. 68)
  - 65. Martien, R., Loretz, B., Thaler, M., Majzoob, S., Bernkop-Schnürch, A.: ‘Chitosan–thioglycolic acid conjugate: an alternative carrier for oral nonviral gene delivery?’, J. Biomed. Mater. Res. A, 2007, 82, (1), pp. 1–9 (doi: 10.1002/jbm.a.31135).
69. 69)
  - 35. Torché, A.-M., Jouan, H., Le Corre, P., et al: ‘Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment’, Int. J. Pharm., 2000, 201, (1), pp. 15–27 (doi: 10.1016/S0378-5173(00)00364-1).

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