In the present scenario, retinal image processing is toiling hard to get an efficient algorithm for de-noising and segmenting the blood vessel confined inside the closed curvature boundary. On this ground, this study presents a hybrid active contour model with a novel preprocessing technique to segment the retinal blood vessel in different fundus images. Contour driven black top-hat transformation and phase-based binarisation method have been implemented to preserve the edge and corner details of the vessels. In the proposed work, gradient vector flow (GVF)-based snake and balloon method are combined to achieve better accuracy over different existing active contour models. In the earlier active contour models, the snake cannot enter inside the closed curvature resulting loss of tiny blood vessels. To circumvent this problem, an inflation term with GVF-based snake is incorporated together to achieve the new internal energy of snake for effective vessel segmentation. The evaluation parameters are calculated over four publically available databases: STARE, DRIVE, CHASE, and VAMPIRE. The proposed model outperforms its competitors by calculating a wide range of proven parameters to prove its robustness. The proposed method achieves an accuracy of 0.97 for DRIVE & CHASE and 0.96 for STARE & VAMPIRE datasets.