Compressors are fundamental components in multi-operand addition and multiplication hardware. The present study aims to propose several high-speed hybrid designs of 4:2 compressors which are implemented based on multi-threshold logic and transmission gate multiplexers, at low supply voltages. In order to implement these circuits, carbon nanotube field-effect transistors (CNFETs) are utilised. The division of the entire input capacitor network in the third proposed design causes the entire structure operates faster and consumes less power. All designs were simulated with Synopsys HSPICE and CNFET technology in different conditions. Simulation results demonstrate the superiority of the third proposed design with regard to different load and frequency conditions. In addition, it becomes less sensitive to process, voltage and temperature variations compared to other similar capacitive threshold logic circuits. The results indicate the third proposed design outperforms the best reference design in terms of delay and power-delay product by 34 and 25%, respectively. Furthermore, the performance of each design was evaluated in a 8 × 8-bit binary multiplier as a uniform test bench, which confirmed the above results on isolated single 4:2 compressors.