Graphene electronic sensors – review of recent developments and future challenges

Oana Moldovan; Benjamin Iñiguez; M. Jamal Deen; Lluis F. Marsal

Graphene electronic sensors – review of recent developments and future challenges

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Author(s): Oana Moldovan ¹ ; Benjamin Iñiguez ¹ ; M. Jamal Deen ² ; Lluis F. Marsal ¹
- Affiliations: 1: Departament d'Enginyeria Electrònica, Elèctrica i Automàtica, Universitat Rovira i Virgili, Avda Països Catalans 26, Tarragona 43007, Spain ;
  2: Electrical and Computer Engineering Department, McMaster University, Hamilton, ON L8S 4K1, Canada
Source: Volume 9, Issue 6, November 2015, p. 446 – 453
DOI: 10.1049/iet-cds.2015.0259 , Print ISSN 1751-858X, Online ISSN 1751-8598

Received 20/08/2015, Accepted 30/09/2015, Published

Electronic sensors based on graphene have a high potential in many applications, due to the unique properties of the graphene material. This study is a review where the authors discuss the properties of graphene which are useful to sensing applications and they report and describe different types of graphene electronic sensors: biological, mechanical, gas and chemical sensors. They also discuss the ways to functionalise graphene and the used device structures. They compare the performance of the main types of biological, mechanical and chemical sensors. Finally, they explain the future challenges of graphene-based sensors, in order to make graphene sensing systems and smart sensors, which would be their main breakthrough application.

References

1. 1)
  - 5. Schwierz, F.: ‘Graphene and beyond: two-dimensional materials for transistor applications’. Proc. SPIE 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII, 94670W, 22 May 2015, doi: 10.1117/12.2177033.
2. 2)
  - 59. Wang, X.L., Bai, H., Shi, G.Q.: ‘Size fractionation of graphene oxide sheets by pH assisted selective sedimentation’, J. Am. Chem. Soc., 2011, 133, pp. 6338–6342 (doi: 10.1021/ja200218y).
3. 3)
  - 54. Shao, Q.H., Liu, G.X., Teweldebrhan, D., et al: ‘Flicker noise in bilayer graphene transistors’, IEEE Electron. Device Lett., 2009, 30, pp. 288–290 (doi: 10.1109/LED.2008.2011929).
4. 4)
  - 55. Schedin, F., Geim, A.K., Morozov, S.V., et al: ‘Detection of individual gas molecules adsorbed on graphene’, Nat. Mater., 2007, 6, pp. 652–655 (doi: 10.1038/nmat1967).
5. 5)
  - 41. Hempel, M., Nezich, D., Kong, J., et al: ‘A novel class of strain gauges based on layered percolative films of 2D materials’, Nano Lett., 2012, 12, pp. 5714–5718 (doi: 10.1021/nl302959a).
6. 6)
  - 58. Ambrosi, A., Pumera, M.: ‘The CVD graphene transfer procedure introduces metallic impurities which alter the graphene electrochemical properties’, Nanoscale, 2014, 6, p. 472 (doi: 10.1039/C3NR05230C).
7. 7)
  - 7. Ray, S.: ‘Applications of graphene and graphene-oxide based nanomaterials’ (William Andrew (Elsevier), Oxford, UK, 2015), ISBN: 978-0-323-37521-4.
8. 8)
  - 26. Mao, S., Lu, G., Yu, K., et al: ‘Specific protein detection using thermally reduced graphene oxide sheet decorated with gold nanoparticle-antibody conjugates’, Adv. Mater., 2010, 22, pp. 3521–3526 (doi: 10.1002/adma.201000520).
9. 9)
  - 74. Ong, K.-G., Zeng, K., Grimes, C.A.: ‘Wireless, passive carbon nanotube-based gas sensor’, IEEE Sens., 2002, 2, pp. 82–88 (doi: 10.1109/JSEN.2002.1000247).
10. 10)
  - 56. He, Q., Wu, S., Yin, Z., et al: ‘Graphene-based electronic sensors’, Chem. Sci., 2012, 3, pp. 1764–1772 (doi: 10.1039/c2sc20205k).
11. 11)
  - 27. He, Q., Wu, S., Gao, S., et al: ‘Transparent, flexible, all-reduced graphene oxide thin film transistors’, ACS Nano, 2011, 5, (6), pp. 5038–5044 (doi: 10.1021/nn201118c).
12. 12)
  - 70. Bogue, R.: ‘Sensor review’, 2014, pp. 233–238.
13. 13)
  - 39. Wang, Y., Yang, R., Shi, Z.W., et al: ‘Super-elastic graphene ripples for flexible strain sensors’, ACS Nano, 2011, 5, pp. 3645–3650 (doi: 10.1021/nn103523t).
14. 14)
  - 103. Feng, L., Chen, Y., Ren, J., et al: ‘A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells’, Biomaterials, 2011, 32, (11), pp. 2930–2937 (doi: 10.1016/j.biomaterials.2011.01.002).
15. 15)
  - 23. Novoselov, K.S., Fal, V., Colombo, L., Gellert, P.P., Schwab, M., Kim, K.: ‘A roadmap for graphene’, Nature, 2012, 490, (7419), pp. 192–200 (doi: 10.1038/nature11458).
16. 16)
  - 1. Novoselov, K.S., Geim, A.K., Morozov, S.V., et al: ‘Electric ﬁeld effect in atomically thin carbon ﬁlms’, Science, 2004, 306, (5696), pp. 666–669 (doi: 10.1126/science.1102896).
17. 17)
  - 13. Wu, H., Wang, J., Kang, X.H., et al: ‘Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite film’, Talanta, 2009, 80, pp. 403–406 (doi: 10.1016/j.talanta.2009.06.054).
18. 18)
  - 22. Stine, R., Robinson, J.T., Sheehan, P.E., et al: ‘Real-time DNA detection using reduced graphene oxide field effect transistors’, Adv. Mater., 2010, 22, pp. 5297–5300 (doi: 10.1002/adma.201002121).
19. 19)
  - 28. Guo, C.X., Zheng, X.T., Lu, Z.S., et al: ‘Biointerface by cell growth on layered graphene–artificial peroxidase–protein nanostructure for in situ quantitative molecular detection’, Adv. Mater., 2010, 22, pp. 5164–5167 (doi: 10.1002/adma.201001699).
20. 20)
  - 37. Huang, M.Y., Pascal, T.A., Kim, H., et al: ‘Simulations electronic–mechanical coupling in graphene from in situ nanoindentation experiments and multiscale atomistic’, Nano Lett., 2011, 11, pp. 1241–1246 (doi: 10.1021/nl104227t).
21. 21)
  - 48. Kreno, L.E., Leong, K., Farha, O.K., et al: ‘Metal-organic framework materials as chemical sensors’, Chem. Rev., 2011, 112, pp. 1105–1125 (doi: 10.1021/cr200324t).
22. 22)
  - 33. Ang, P.K., Li, A., Jaiswal, M., et al: ‘Flow sensing of single cell by graphene transistor in a microfluidic channel’, Nano Lett., 2011, 11, pp. 5240–5246 (doi: 10.1021/nl202579k).
23. 23)
  - 32. He, Q.Y., Sudibya, H.G., Yin, Z.Y., et al: ‘Centimeter-long and large-scale micropatterns of reduced graphene oxide films: fabrication and sensing applications’, ACS Nano, 2010, 4, pp. 3201–3208 (doi: 10.1021/nn100780v).
24. 24)
  - 14. Zeng, Q., Cheng, J.-S., Liu, X.-F., et al: ‘Palladium nanoparticle/chitosan-grafted graphene nanocomposites for construction of a glucose biosensor’, Biosens. Bioelectron., 2011, 26, p. 3456 (doi: 10.1016/j.bios.2011.01.024).
25. 25)
  - 19. Wang, Z., Zhang, J., Chen, P., et al: ‘Label-free, electrochemical detection of methicillin-resistant Staphylococcus aureus DNA with reduced graphene oxide-modified electrodes’, Biosens. Bioelectron., 2011, 26, pp. 3881–3886 (doi: 10.1016/j.bios.2011.03.002).
26. 26)
  - 50. Pumera, M., Ambrosi, A., Bonanni, A., et al: ‘Graphene for electrochemical sensing and biosensing’, Trends Anal. Chem., 2010, 29, pp. 954–965 (doi: 10.1016/j.trac.2010.05.011).
27. 27)
  - 72. Collins, P., Bradley, K., Ishigami, M., et al: ‘Extreme oxygen sensitivity of electronic properties of carbon nanotubes’, Science, 2000, 287, pp. 1801–1804 (doi: 10.1126/science.287.5459.1801).
28. 28)
  - 18. Yuan, W., Shi, G.: ‘Graphene-based gas sensors’, J. Mater. Chem. A, 2013, 1, (35), pp. 10078–10091 (doi: 10.1039/c3ta11774j).
29. 29)
  - 6. Hill, C.W., Vijayaragahvan, A., Novoselov, K.: ‘Graphene sensors’, IEEE Sens. J., 2011, 11, (12), pp. 3161–3170 (doi: 10.1109/JSEN.2011.2167608).
30. 30)
  - 23. Su, B.L., Tang, J.A., Huang, J.X., et al: ‘Graphene and nanogold-functionalized immunosensing interface with enhanced sensitivity for one-step electrochemical immunoassay of alpha-fetoprotein in human serum’, Electroanalysis, 2010, 22, pp. 2720–2728 (doi: 10.1002/elan.201000324).
31. 31)
  - 35. Fu, X.W., Liao, Z.M., Zhou, J.X., et al: ‘Strain dependent resistance in chemical vapor deposition grown graphene’, Appl. Phys. Lett., 2011, 99, p. 213107 (doi: 10.1063/1.3663969).
32. 32)
  - 75. Modi, A., Koratkar, N., Lass, E., et al: ‘Miniaturized gas ionization sensors using carbon nanotubes’, Nature, 2003, 424, pp. 171–174 (doi: 10.1038/nature01777).
33. 33)
  - 65. Inaba, A., Yoo, K., Takei, Y., et al: ‘Ammonia gas sensing using a graphene field-effect transistor gated by ionic liquid’, Sens. Actuators B, 2014, 195, pp. 15–21 (doi: 10.1016/j.snb.2013.12.118).
34. 34)
  - 40. Kim, Y.J., Cha, J.Y., Ham, H., et al: ‘Preparation of piezoresistive nano smart hybrid material based on graphene’, Curr. Appl. Phys., 2011, 11, pp. S350–S352 (doi: 10.1016/j.cap.2010.11.022).
35. 35)
  - 52. Ratinac, K.R., Yang, W., Ringer, S.P., et al: ‘Toward ubiquitous environmental gas sensors – capitalizing on the promise of graphene’, Environ. Sci. Technol., 2010, 44, pp. 1167–1176 (doi: 10.1021/es902659d).
36. 36)
  - 38. Robinson, J.T., Perkins, F.K., Snow, E.S., et al: ‘Reduced graphene oxide molecular sensors’, Nano Lett., 2008, 8, (10), pp. 3137–3140 (doi: 10.1021/nl8013007).
37. 37)
  - 67. http://www.graphene-info.com/graphene-sensors.
38. 38)
  - 75. Wang, Y., Shao, Y., Matson, D.W., et al: ‘Nitrogen-doped graphene and its application in electrochemical biosensing’, ACS Nano, 2010, 4, (4), pp. 1790–1798 (doi: 10.1021/nn100315s).
39. 39)
  - 4. Huang, Y., Dong, X., Liu, Y., Li, L.-J., Chen, P.P.: ‘Graphene-based biosensors for detection of bacteria and their metabolic activities’, J. Mater. Chem., 2011, 21, (33), pp. 12358–12362 (doi: 10.1039/c1jm11436k).
40. 40)
  - 11. Alwarappan, S., Liu, C., Kumar, A., et al: ‘Enzyme-doped graphene nanosheets for enhanced glucose biosensing’, J. Phys. Chem. C, 2010, 114, pp. 12920–12924 (doi: 10.1021/jp103273z).
41. 41)
  - 73. Kong, J., Franklin, N., Zhou, C., et al: ‘Nanotube molecular wires as chemical sensors’, Science, 2000, 287, pp. 622–625 (doi: 10.1126/science.287.5453.622).
42. 42)
  - 47. Li, C., Bai, H., Shi, G.Q.: ‘Conducting polymer nanomaterials: electrosynthesis and applications’, Chem. Soc. Rev., 2009, 38, pp. 2397–2409 (doi: 10.1039/b816681c).
43. 43)
  - 71. Nemade, K.R., Waghuley, S.A.: ‘Highly responsive carbon dioxide sensing by graphene/Al2O3 quantum dots composites at low operable temperature’, Indian J. Phys., 2014, 88, pp. 577–583 (doi: 10.1007/s12648-014-0454-1).
44. 44)
  - 18. Du, M., Yang, T., Jiao, K.: ‘Immobilization-free direct electrochemical detection for DNA specific sequences based on electrochemically converted gold nanoparticles/graphene composite film’, J. Mater. Chem., 2010, 20, pp. 9253–9260 (doi: 10.1039/c0jm01549k).
45. 45)
  - 34. Chen, H.-J., Zhu, K.-D.: ‘Graphene-based nanoresonator with applications in optical transistor and mass sensing’, Sensors, 2014, 14, pp. 16740–16753 (doi: 10.3390/s140916740).
46. 46)
  - 31. Castillo, J.J., Svendsen, W.E., Rozlosnik, N., et al: ‘Detection of cancer cells using a peptide nanotube–folic acid modified graphene electrode’, Analyst, 2013, 138, pp. 1026–1031 (doi: 10.1039/C2AN36121C).
47. 47)
  - 44. Zhao, J., He, C.L., Yang, R., et al: ‘Ultra-sensitive strain sensors based on piezoresistive nanographene films’, Appl. Phys. Lett., 2012, 101, p. 063112 (doi: 10.1063/1.4742331).
48. 48)
  - 10. Wu, P., Shao, Q., Hu, Y., et al: ‘Direct electrochemistry of glucose oxidase assembled on graphene and application to glucose detection’, Electrochim. Acta, 2010, 55, pp. 8606–8614 (doi: 10.1016/j.electacta.2010.07.079).
49. 49)
  - 21. Dong, X., Shi, Y., Huang, W., et al: ‘Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets’, Adv. Mater., 2010, 22, pp. 1649–1653 (doi: 10.1002/adma.200903645).
50. 50)
  - 68. Pak, Y., Kim, S.-M., Jeong, H., et al: ‘Palladium-decorated hydrogen-gas sensors using periodically aligned graphene nanoribbons’, ACS Appl. Mater. Interfaces, 2014, 6, (15), pp. 13293–13298 (doi: 10.1021/am503105s).
51. 51)
  - 57. Carbone, M., Gorton, L., Antiochia, R.: ‘An overview of the latest graphene-based sensors for glucose detection: the effects of graphene defects’, Electroanalysis, 2015, 27, pp. 16–31 (doi: 10.1002/elan.201400409).
52. 52)
  - 53. Lin, Y.M., Avouris, P.: ‘Strong suppression of electrical noise in bilayer graphene nanodevices’, Nano Lett., 2008, 8, pp. 2119–2125 (doi: 10.1021/nl080241l).
53. 53)
  - 8. Rao, N.R., Gopalakrishnan, K., Maltra, U.: ‘Comparative study of potential applications of graphene, MoS2, and other two-dimensional materials in energy devices, sensors, and related areas’, ACS Appl. Mater. Interfaces, 2015, 7, (15), pp. 7809–7832 (doi: 10.1021/am509096x).
54. 54)
  - 20. Zhang, J., Lei, J.P., Pan, R., et al: ‘Highly sensitive electrocatalytic biosensing of hypoxanthine based on functionalization of graphene sheets with water-soluble conducting graft copolymer’, Biosens. Bioelectron., 2010, 26, pp. 371–376 (doi: 10.1016/j.bios.2010.07.127).
55. 55)
  - 61. Dua, V., Surwade, S.P., Ammu, S., et al: ‘All organic vapor sensor using inkjet-printed reduced graphene oxide’, Angew Chem. Int. Ed., 2010, 49, pp. 2154–2157 (doi: 10.1002/anie.200905089).
56. 56)
  - 66. Eisele, I., Doll, T., Burgmair, M.: ‘Low power gas detection with FET sensors’, Sens. Actuators B, 2001, 78, pp. 19–25 (doi: 10.1016/S0925-4005(01)00786-9).
57. 57)
  - 64. Choi, H.K., Jeong, H.Y., Lee, D.-S., et al: ‘Flexible NO2 gas sensor using multilayer graphene films by chemical vapor deposition’, Carbon Lett., 2013, 3, pp. 186–189 (doi: 10.5714/CL.2013.14.3.186).
58. 58)
  - 42. Li, X., Zhang, R.J., Yu, W.J., et al: ‘Stretchable and highly sensitive graphene-on-polymer strain sensors’, Sci. Rep. UK, 2012, 2, p. 2870.
59. 59)
  - 16. Huang, Y.X., Dong, X.C., Shi, Y.M., et al: ‘Nanoelectronic biosensors based on CVD grown graphene’, Nanoscale, 2010, 2, pp. 1485–1488 (doi: 10.1039/c0nr00142b).
60. 60)
  - 2. Sanchez, V.C., Jachak, A., Hurt, R.H., et al: ‘Biological interactions of graphene-family nanomaterials: an interdisciplinary review’, Chem. Res. Toxicol., 2012, 25, pp. 15–34 (doi: 10.1021/tx200339h).
61. 61)
  - 69. Hasani, A., Dehsari, H.S., Nasrollah, J., et al: ‘Sensor for volatile organic compounds using an interdigitated gold electrode modified with a nanocomposite made from poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) and ultra-large graphene oxide’, Microchim. Acta, 2015, 182, pp. 1551–1559 (doi: 10.1007/s00604-015-1487-7).
62. 62)
  - 12. Shan, C.S., Yang, H.F., Han, D.X., et al: ‘Graphene/AuNPs/chitosan nanocomposites film for glucose biosensing’, Biosens. Bioelectron., 2010, 25, pp. 1070–1074 (doi: 10.1016/j.bios.2009.09.024).
63. 63)
  - 45. Eswaraiah, V., Balasubramaniam, K., Ramaprabhu, S.: ‘One-pot synthesis of conducting graphene-polymer composites and their strain sensing application’, Nanoscale, 2012, 4, pp. 1258–1262 (doi: 10.1039/c2nr11555g).
64. 64)
  - 63. Guo, L., Jiang, H.B., Shao, R.Q., et al: ‘Two-beam-laser interference mediated reduction, patterning and nanostructuring of graphene oxide for the production of a flexible humidity sensing device’, Carbon, 2012, 50, pp. 1667–1673 (doi: 10.1016/j.carbon.2011.12.011).
65. 65)
  - 25. Han, J., Ma, J., Ma, Z.: ‘One-step synthesis of graphene oxide–thionine–Au nanocomposites and its application for electrochemical immunosensing’, Biosens. Bioelectron., 2013, 47, pp. 243–247 (doi: 10.1016/j.bios.2013.03.032).
66. 66)
  - 3. Kuila, T., Bose, S., Khanra, P., et al: ‘Recent advances in graphene-based biosensors’, Biosens. Bioelectron., 2011, 26, pp. 4637–4648 (doi: 10.1016/j.bios.2011.05.039).
67. 67)
  - 17. Huang, K.J., Niu, D.J., Sun, J.Y., et al: ‘Novel electrochemical sensor based on functionalized graphene for simultaneous determination of adenine and guanine in DNA’, Colloids Surf., B, 2011, 82, pp. 543–549 (doi: 10.1016/j.colsurfb.2010.10.014).
68. 68)
  - 9. Kumar Vashist, S., Venkatesh, A.G.: ‘Advances in graphene-based sensors and devices’, J. Nanomed. Nanotechnol., 2012, 4 (1).
69. 69)
  - 4. Cui, S., Mao, S., Lu, G., et al: ‘Graphene coupled with nanocrystals: opportunities and challenges for energy and sensing applications’, J. Phys. Chem. Lett., 2013, 4, pp. 2441–2454 (doi: 10.1021/jz400976a).
70. 70)
  - 46. Wagner, T., Haffer, S., Weinberger, C., et al: ‘Mesoporous materials as gas sensors’, Chem. Soc. Rev., 2013, 42, pp. 4036–4053 (doi: 10.1039/C2CS35379B).
71. 71)
  - 38. Lee, Y., Bae, S., Jang, H., et al: ‘Wafer-scale synthesis and transfer of graphene films’, Nano Lett., 2010, 10, pp. 490–493 (doi: 10.1021/nl903272n).
72. 72)
  - 24. Xie, Y., Chena, A., Dua, D., et al: ‘Graphene-based immunosensor for electrochemical quantification of phosphorylated p53 (S15)’, Anal. Chim. Acta, 2011, 699, pp. 44–48 (doi: 10.1016/j.aca.2011.05.010).
73. 73)
  - 36. Jing, Z., Guang-Yu, Z., Dong-Xia, S.: ‘Review of graphene-based strain sensors’, Chin. Phys. B, 2013, 22, (5), p. 057701 (doi: 10.1088/1674-1056/22/5/057701).
74. 74)
  - 60. Xu, Y.X., Shi, G.Q.: ‘Assembly of chemically modified graphene: methods and applications’, J. Mater. Chem., 2011, 21, pp. 3311–3323 (doi: 10.1039/C0JM02319A).

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