Synthetic biology is transforming the ability to manufacture increasingly needed bio-based products in response to rising market demand. By applying engineering principles to the convolution of recent advances in genomic engineering techniques, information technology and automation, synthetic biology is facilitating the replacement of time-consuming ‘discover and grow’ approaches by more precise and affordable ‘biodesign and biomanufacture’ processes. Meantime, societal awareness of specific health, well-being, and environmental issues is increasing ‘market pull’ that will shape future pathways to commercialisation. Market interests will not only shape targets for product function and cost but also increasingly question their provenance. Sustainability concerns are already driving demand to replace petrochemical-derived by bio-derived products, but many established industries wishing to transition may lack familiarity with bio-manufacturing processes and with the wider issues associated with large-scale bio-feedstock supply chains. Meantime, commercialisation of synthetic biology today is being advanced mostly via start-ups and SMEs. Combining the knowledge and skills required to respond to market interests, as the scale of operations and complexity of issues expands, is likely to stimulate an increasing diversity of collaborative approaches.

References

1. 1)
  - 13. Policy Paper: ‘Bioeconomy strategy 2018 – 2030’. Available at https://www.gov.uk/government/publications/bioeconomy-strategy-2018-to-2030, accessed December 2018.
2. 2)
  - 35. Patel, P.: ‘Tech turns to biology as data storage needs explode’ (Scientific American, 2016). Available at https://www.scientificamerican.com/article/tech-turns-to-biology-as-data-storage-needs-explode/, accessed December 2018.
3. 3)
  - 29. Hardcastle, J.L.: ‘BASF, genomatica expand biochemical production’ (Environmental Leader, 2015). Available at https://www.environmentalleader.com/2015/09/basf-genomatica-expand-biochemical-production/, accessed December 2018.
4. 4)
  - 20. National Research Council: ‘Industrialization of biology – a roadmap to accelerate the advanced manufacturing of chemicals’ (The National Academies Press, 2015), p. 46.
5. 5)
  - 30. ‘Amyris’. Available at https://amyris.com, accessed December 2018.
6. 6)
  - 36. ‘Customem’. Available at https://www.customem.com, accessed December 2018.
7. 7)
  - 38. ‘Impossible Foods’. Available at https://impossiblefoods.com, accessed December 2018.
8. 8)
  - 27. ‘Sustainability Research, November 2017’. Available at https://www.genomatica.com/wp-content/uploads/ICIS_Genomatica_2017_survey_final.pdf, accessed December 2018.
9. 9)
  - 9. ‘Bento Lab’. Available at https://www.bento.bio, accessed December 2018.
10. 10)
  - 26. ‘Jet Fuel Derived from ethanol now eligible for commercial flights’. Available at http://www.lanzatech.com/jet-fuel-derived-ethanol-now-eligible-commercial-flights/, accessed December 2018.
11. 11)
  - 6. Polizzi, K.M., Stanbrough, L., Heap, J.T.: ‘A new lease of life: understanding the risks of synthetic biology. An emerging risks report published by Lloyds of London report’, 2018.
12. 12)
  - 4. ‘A Synthetic Biology Roadmap for the UK’, 2012. Available at https://www.gov.uk/government/groups/synthetic-biology-leadership-council#synthetic-biology-roadmap-for-the-uk-2012, accessed December 2018.
13. 13)
  - 10. Gleeson, A.: ‘The new synthesis’ (Biotechniques, 2018). Available at https://www.future-science.com/btn/news/jun18/25, accessed December 2018.
14. 14)
  - 14. Weiss, R., Panke, S.: ‘Synthetic biology – paths to moving forward’, Curr. Opin. Biotechnol., 2009, 20, pp. 447–448.
15. 15)
  - 17. ‘Sustainable Development Goals’. Available at https://www.un.org/sustainabledevelopment/sustainable-development-goals/, accessed December 2018.
16. 16)
  - 28. ‘The Sorona Story’. Available at http://sorona.com/our-story/, accessed December 2018.
17. 17)
  - 11. ‘Emerging Policy Issues in Synthetic Biology’ OECD (2014), p 81.
18. 18)
  - 41. Kansara, V.A.: ‘With lab-grown leather, modern meadow is engineering a fashion revolution’ (Business of Fashion, 2017). Available at https://www.businessoffashion.com/articles/fashion-tech/bof-exclusive-with-lab-grown-leather-modern-meadow-is-bio-engineering-a-fashion-revolution, accessed December 2018.
19. 19)
  - 19. ‘Plastic Oceans: MEPs back EU ban on throwaway plastics by 2021’. Available at http://www.europarl.europa.eu/news/en/press-room/20181018IPR16524/plastic-oceans-meps-back-eu-ban-on-throwaway-plastics-by-2021, accessed December 2018.
20. 20)
  - 16. Katowice Climate Change Conference (COP24). Available at https://unfccc.int/katowice, accessed December 2018.
21. 21)
  - 18. ‘Plastic Pollution in the Ocean’, (Grantham Institute). Available at https://www.imperial.ac.uk/grantham/our-work/earth-systems-variability-and-change/plastic-pollution-in-the-ocean/, accessed December 2018.
22. 22)
  - 3. Clarke, L.J.: ‘Synthetic biology UK: progress, paradigms and prospects’, Eng. Biol., 2017, 1, (2), pp. 66–70.
23. 23)
  - 32. ‘Versalis and Genomatica Produce Bio-Rubber With Bio-Butadiene From Sugars’. Available at https://www.genomatica.com/wp-content/uploads/2017/01/Versalis-and-Genomatica-produce-bio-rubber-with-bio-butadiene-from-sugars.pdf, accessed December 2018.
24. 24)
  - 40. Murray, J.: ‘From cell culture to table culture: food tech comes alive’, 26 June 2018. Available at https://synbiobeta.com/food-tech-comes-alive/, accessed December 2018.
25. 25)
  - 23. Clarke, L.J.: ‘Biofuels in operation’, in Love, J., Bryant, J.A. (Eds.): ‘Biofuels and bioenergy’ (Wiley Blackwell, 2017), ch. 2, pp. 21–44.
26. 26)
  - 33. ‘Living Foundries’. Available at https://www.darpa.mil/program/living-foundries, accessed December 2018.
27. 27)
  - 25. ‘Standard Specification for Aviation Turbine Fuel Containing Synthesized Hydrocarbons’, ASTM D7566, Annex A5. Available at https://www.astm.org/Standards/D7566.htm, accessed December 2018.
28. 28)
  - 1. ‘Beyond Borders – staying the course’, EY Biotechnology Report 2017. Available at https://www.ey.com/Publication/vwLUAssets/ey-biotechnology-report-2017-beyond-borders-staying-the-course/$FILE/ey-biotechnology-report-2017-beyond-borders-staying-the-course.pdf, accessed December 2018.
29. 29)
  - 12. ‘Biotechnology Market worth $727.1 million by 2025’. Available at https://www.grandviewresearch.com/press-release/global-biotechnology-market, accessed December 2018.
30. 30)
  - 21. ‘The bioeconomy to 2030: designing a policy agenda’ (OECD Publishing, 2009).
31. 31)
  - 8. ‘Sphere Fluidics’. Available at https://www.amadeuscapital.com/company/sphere-fluidics/, accessed December 2018.
32. 32)
  - 24. Lange, J.-P., Price, R., Ayoub, P.M., et al: ‘Valeric biofuels: a platform of cellulosic transportation fuels’, Angew. Chem. Int. Ed., 2010, 49, pp. 4479–4483.
33. 33)
  - 31. ‘Green Biologics’. Available at http://www.greenbiologics.com/index.php, accessed December 2018.
34. 34)
  - 37. ‘Colorifix’. Available at http://www.colorifix.com/Colorifix/page.php, accessed December 2018.
35. 35)
  - 43. ‘Fashioned from Nature’ (2018) Foreword by Emma Watson, ed., Edwina Ehrman.
36. 36)
  - 39. ‘SynbioBeta quarterly investment update’. Available at https://synbiobeta.com/these-33-synthetic-biology-companies-just-raised-925-million/, accessed December 2018.
37. 37)
  - 7. ‘100,000 Genomes Project’. Available at https://www.genomicsengland.co.uk, accessed December 2018.
38. 38)
  - 22. ‘Sky: meeting the goals of the Paris agreement’, Shell 27 March 2018. Available at https://www.shell.com/energy-and-innovation/the-energy-future/scenarios/shell-scenario-sky.html, accessed December 2018.
39. 39)
  - 15. ‘The Paris Agreement’. Available at https://unfccc.int/process-and-meetings/the-paris-agreement/the-paris-agreement, accessed December 2018.
40. 40)
  - 5. Clarke, L.J., Kitney, R.I.: ‘Synthetic biology in the UK – an outline of plans and progress’, Synth. Syst. Biol., 2016, 1, pp. 243–257.
41. 41)
  - 2. Kuhn, T.S.: ‘The structure of scientific revolutions’ (University of Chicago Press, Chicago, 1962).
42. 42)
  - 42. ‘Bolt Threads’. Available at https://boltthreads.com, accessed December 2018.
43. 43)
  - 34. Le Feuvre, R.A., Scrutton, N.S.: ‘A living foundry for synthetic biological materials: a synthetic biology roadmap to new advanced materials’, Synth. Syst. Biotechnol., 2018, 3, (2), pp. 105–112.

Synthetic biology – pathways to commercialisation

References

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