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access icon openaccess Genome-scale model of C. autoethanogenum reveals optimal bioprocessconditions for high-value chemical production from carbon monoxide

Clostridium autoethanogenum is an industrial microbe used for thecommercial-scale production of ethanol from carbon monoxide. While significant progress has beenmade in the attempted diversification of this bioprocess, further improvements are desirable,particularly in the formation of the high-value platform chemicals such as 2,3-butanediol (2,3-BD).A new, experimentally parameterised genome-scale model of C. autoethanogenumpredicts dramatically increased 2,3-BD production under non-carbon-limited conditions whenthermodynamic constraints on hydrogen production are considered.

http://iet.metastore.ingenta.com/content/journals/10.1049/enb.2018.5003
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content/journals/10.1049/enb.2018.5003
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