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Gold nanoparticle distribution monitor for drug delivery system based on optically assisted ultrasonic velocity-change imaging

Gold nanoparticle distribution monitor for drug delivery system based on optically assisted ultrasonic velocity-change imaging

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Optical absorption images of the tissue mimic phantom including gold nanoparticles were obtained by detecting the ultrasonic velocity-change caused by light irradiation. A series of experimental results showed the possibility as a nanoparticle distribution monitor for the drug delivery system.

References

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      • X. Huang , I.H. El-Sayed , W. Qian , M.A. El-Sayed . Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc. , 2115 - 2120
    2. 2)
      • Horinaka, H., Wada, K., Okasaka, A., Cho, Y., Matsunaka, T., Saimi, S.: `Optical computed tomography imaging of absorbers hidden in scattering medium by detection of ultrasonic phase-shift caused by laser illumination', Proc. 2000 IEEE Ultrasonic Symp., 2000, Puerto Rico, p. 1709–1712.
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      • Horinaka, H., Matsunaka, T., Ura, T., Mukaiyama, T., Nakamura, N., Wada, K.: `Real time optical tomography of biological tissue by detection of ultrasonic velocity change due to light illumination', Proc. 2006 IEEE Ultrasonic Symp., 2006, Vancouver, p. 2060–2063.
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