Rheological monitoring of tau protein polymerisation with acoustic waves sensor

P. Didier; F. Razan; E. Caplain; M. Michiel; C. Delamarche; C. Nogues; J.Y. Le Huerou; S. Serfaty; P. Larzabal

Rheological monitoring of tau protein polymerisation with acoustic waves sensor

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Author(s): P. Didier ¹ ; F. Razan ¹ ; E. Caplain ¹ ; M. Michiel ¹ ; C. Delamarche ² ; C. Nogues ³ ; J.Y. Le Huerou ¹ ; S. Serfaty ¹ ; P. Larzabal ¹
- Affiliations: 1: SATIE, UMR CNRS 8029, ENS Cachan, 61 Avenue du Président Wilson, 94235 Cachan, France ;
  2: IGDR, UMR CNRS 6290, Campus de Beaulieu, Universite de Rennes 1, Bât. 13, 35042 Rennes, France ;
  3: LBPA, UMR CNRS 8113, ENS Cachan, Ecole Normale Superieure de Cachan, 61 Avenue du Président Wilson, 94235 Cachan, France
Source: Volume 53, Issue 5, 02 March 2017, p. 298 – 300
DOI: 10.1049/el.2016.3400 , Print ISSN 0013-5194, Online ISSN 1350-911X

Received 04/10/2016, Published 19/01/2017

Among acoustic waves sensors, the thickness shear mode resonator presents high sensitivity for the measurement of liquid viscoelastic properties, enabling the monitoring of the shear moduli, G′ G″, by using a suitable physical model. The development of an instrumental system for detecting the tau protein involved in Alzheimer's disease is proposed which will aid in understanding the mechanisms of this disease. The tau protein is present in complex products such as blood and cerebrospinal fluid. The experimental results show that the acoustic wave system allows to differentiate between tau protein solutions with different states of polymerisation.

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