access icon free LED die-on-chip integration for fluorescence-detection applications

Conventional fluorescence-detection systems typically involve a separate laser excitation source shining directly down towards the photodetectors, with the fluorescent sample in-between. A major issue with such systems is the strong excitation light signal that can saturate detection circuitry and/or make detection of the fluorescent signal difficult, even with optical filtering. A fluorescence-detection system is described consisting of light emitting diode dies bonded on top of a CMOS imaging chip. Such a system facilitates a high level of integration while potentially reducing the excitation light hitting the photodetectors. Model results are used to predict the shape of the imager response to excitation light. Experimental results confirm the validity of the model.

Inspec keywords: light emitting diodes; CMOS integrated circuits; fluorescence; photodetectors

Other keywords: fluorescent sample; fluorescent signal; strong excitation light signal; LED die-on-chip integration; detection circuitry; fluorescence-detection applications; imager response; photodetectors; light emitting diode dies; optical filtering; CMOS imaging chip; laser excitation source

Subjects: Light emitting diodes; Photodetectors; CMOS integrated circuits

References

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      • 4. Ohta, J., Tagawa, A., Minami, H., et al: ‘A multimodal sensing device for fluorescence imaging and electrical potential measurement of neural activities in a mouse deep brain’. EMBC Conf., Minneapolis, MN, USA, September 2009, pp. 58875890.
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      • 1. Singh, R.R., Ho, D., Nilchi, A., et al: ‘A CMOS/thin-film fluorescence contact imaging microsystem for DNA analysis’, IEEE Trans. Circuits Syst. I, 2010, 57, (5), pp. 10291038 (doi: 10.1109/TCSI.2010.2043990).
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