ISFET technology for multi-sensor technology: from lab-in-a-pill to massively parallel measurements
ISFET technology for multi-sensor technology: from lab-in-a-pill to massively parallel measurements
- Author(s): D.R.S. Cumming
- DOI: 10.1049/el.2011.2891
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- Author(s): D.R.S. Cumming 1
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View affiliations
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Affiliations:
1: School of Engineering, University of Glasgow, Glasgow, United Kingdom
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Affiliations:
1: School of Engineering, University of Glasgow, Glasgow, United Kingdom
- Source:
Volume 47, Issue 26,
22 December 2011,
p.
14 – 16
DOI: 10.1049/el.2011.2891 , Print ISSN 0013-5194, Online ISSN 1350-911X
© The Institution of Engineering and Technology
Published
Laboratory-in-a-pill, or capsule endoscopy, became a reality almost as soon as the invention of the transistor enabled miniaturisation of circuits into a small enough device. Of the many possible sensor modalities pH has emerged as an important measurand for diagnostics and laboratory analysis. Presented is the background to the early instances of the technology, including a summary of the published work on pill-based diagnostic devices. Then, how concepts from pill technology have led to further sensor integration, and to sensor system on chip (SSOC) in particular is presented. To conclude, consideration is given to how many ISFETs have been integrated using SSOC technology, and how this technology has led to the development of post-light gene sequencing systems using CMOS.
Inspec keywords: genetics; biosensors; lab-on-a-chip; biomedical electronics; pH; ion sensitive field effect transistors
Other keywords:
Subjects: Chemical variables measurement; Insulated gate field effect transistors; Biosensors; Physics of subcellular structures; Chemical sensors; Biosensors; Chemical sensors
References
-
-
1)
- H.J. Park , I.Y. Park , J.W. Lee , B.S. Song , C.H. Won , J.H. Cho . Design of miniaturized telemetry module for bi-directional wireless endoscopes. IEICE Trans. Fundam. Electron. Commun. Comput. Sci. , 6 , 1487 - 1491
-
2)
- M. Skidmore . Mini transmitter saves babies. NASA Aerosp. Technol. Innov. , 1 , 7 - 8
-
3)
- Beckman, A.O.: `Apparatus for recording acidity', US Patent No. 2,058,761, 12 Oct. 1934.
-
4)
- Milgrew, M.J., Cumming, D.R.S., Riehle, M.O.: `A 16×16 CMOS proton camera array for direct extracellular imaging of hydrogen-ion activity', IEEE Solid-State Circuits Conf., Dig. Tech. Pprs, 2008, Grenoble, France, p. 590–638.
-
5)
- N.J. Clear , A. Milton , M. Humphrey , B.T. Henry , M. Wulff , D.J. Nichols , R.J. Anziano , I. Wilding . Evaluation of the Intelisite capsule to deliver theophyline and frusemide tablets to the small intestine and colon. Eur. J. Pharmaceut. Sci. , 375 - 384
-
6)
- H.G. Noeller . The use of a radiotransmitter capsule for the measurement of gastric pH. German Med. Mon. , 3
-
7)
- L. Phee , D. Accoto , A. Menciassi , C. Stefanini , M.C. Carrozza , P. Dario . Analysis and development of locomotion devices for the gastrointestinal tract. IEEE Trans. Biomed. Eng. , 6 , 613 - 616
-
8)
- J.E. Pandolfino , J.E. Ritcher , T. Ours , R.N. Jason , M. Guardino , J. Chapman , P.J. Kahrilas . Ambulatory esophageal pH monitoring using a wireless system. Am. J. Gastroenterol. , 4 , 740 - 749
-
9)
- S.J. Meldrum , B.W. Watson , H.C. Riddle , R.L. Brown , G.E. Sladen . pH profile of gut as measured by radiotelemetry capsule. Br. Med. J. , 5805 , 104 - 106
-
10)
- P. Bergveld . Development of an ion-sensitive solid-state device for neurophysiology measurements. IEEE Trans. Biomed. Eng. , 1 , 70 - 71
-
11)
- A.G. Press , I.A. Hauptmann , B. Fuchs , M. Fuchs , K. Ewe , G. Ramadori . Gastrointestinal pH profiles in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. , 673 - 678
-
12)
- E.A. Johannessen , L. Wang , S.W.J. Reid , D.R.S. Cumming , J.M. Cooper . Implementation of radiotelemetry in a lab-in-a-pill format. Lab Chip , 1 , 39 - 45
-
13)
- J.T. Farrar , V.K. Zworykin , J. Baum . Pressure-sensitive telemetering capsule for study of gastrointestinal motility. Science , 975 - 976
-
14)
- M. Sendoh , K. Ishiyama , K.I. Arai . Fabrication of magnetic actuator for use in a capsule endoscope. IEEE Trans. Magn. , 5 , 3232 - 3234
-
15)
- J.M. Rothberg , W. Hinz , T.M. Rearick , J. Schultz , W. Mileski , M. Davey , J.H. Leamon , K. Johnson , M.J. Milgrew , M. Edwards , J. Hoon , J.F. Simons , D. Marran , J.W. Myers , J.F. Davidson , A. Branting , J.R. Nobile , B.P. Puc , D. Light , T.A. Clark , M. Huber , J.T. Branciforte , I.B. Stoner , S.E. Cawley , M. Lyons , Y. Fu , N. Homer , M. Sedova , X. Miao , B. Reed , J. Sabina , E. Feierstein , M. Schorn , M. Alanjary , E. Dimalanta , D. Dressman , R. Kasinskas , T. Sokolsky , J.A. Fidanza , E. Namsaraev , K.J. McKernan , A. Williams , G.T. Roth , J. Bustillo . An integrated semiconductor device enabling non-optical genome sequencing. Nature , 7356 , 348 - 352
-
16)
- L. Wang , T.D. Drysdale , D.R.S. Cumming . In situ characterization of two wireless transmission schemes for ingestible capsules. IEEE Trans. Biomed. Eng. , 11 , 2020 - 2027
-
17)
- J. Bausells , J. Carrabina , A. Errachid , A. Merlos . Ion-sensitive field-effect transistors fabricated in a commercial CMOS technology. Sens. Actuators B , 56 - 62
-
18)
- Y. Sasaki , R. Hada , H. Nakajima , S. Fukada , A. Munakata . Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn's disease. Am. J. Gastroenterol. , 1 , 114 - 118
-
19)
- Antoniazzi, L., Hua, H.T., Streets, C.G.: `Comparison of normal values obtained with the BRAVO, a catheter-free system, and conventional esophageal pH monitoring', Digestive Disease Week 2002, 2002, USA, abstract no. M1700.
-
20)
- P.A. Hammond , D. Ali , D.R.S. Cumming . A system-on-chip digital pH meter for use in a wireless diagnostic capsule. IEEE Trans. Biomed. Eng , 4 , 687 - 694
-
21)
- W. Weitschies , M. Karaus , D. Cordini , L. Trahms , J. Breitkreutz , W. Semmler . Magnetic marker monitoring of disintegrating capsules. Eur. J. Pharmaceut. Sci. , 411 - 416
-
22)
- Guo, S., Sugimoto, K., Fukuda, T., Oguro, K.: `A new type of capsule medical micropump', Proc. of 19th IEEE/ASME Int. Conf. on Advanced Intelligent Mechatronics, 1999, Atlanta, GA, USA, p. 55–60.
-
23)
- L.C. Chirwa , P.A. Hammond , S. Roy , D.R.S. Cumming . Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz. IEEE Trans. Biomed. Eng. , 4 , 484 - 492
-
24)
- T.B. Tang , E.A. Johannessen , L. Wang , A. Astaras , M. Ahmadian , A.F. Murray , J.M. Cooper , S.P. Beaumont , B.W. Flynn , D.R.S. Cumming . Towards a miniature wireless integrated multisensor microsystem for industrial and biomedical applications. IEEE Sens. J. , 6 , 628 - 635
-
25)
- R.S. Mackay , B. Jacobson . Endoradiosonde. Nature , 1239 - 1240
-
26)
- Casper, R.A.: `Medical capsule device actuated by radio-frequency (RF) signal', USA Patent No. 5,170,801, 1992.
-
27)
- L. Wang , E.A. Johannessen , P.A. Hammond , L. Cui , S.W.J. Reid , J.M. Cooper , D.R.S. Cumming . A programmable microsystem using system-on-chip for real-time biotelemetry. IEEE Trans. Biomed. Eng , 7 , 1251 - 1260
-
28)
- M.J. Milgrew , M.O. Riehle , D.R.S. Cumming . A large transistor-based sensor array chip for direct extracellular imaging. Sens. Actuators B, Chem. , 347 - 353
-
29)
- O. Okundu , W.A.C. Wai , A.J. Burdett , C. Toumazou . Energy efficient Medium Access Protocol for wireless medical body area sensor networks. IEEE Trans. Biomed. Circuits Syst. , 4 , 251 - 259
-
30)
- G. Iddan , G. Meron , A. Glukhovsky , P. Swain . Wireless capsule endoscopy. Nature
-
1)
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