This paper investigates a problem with regard to predictive tracking control for the longitudinal dynamics of a hypersonic vehicle (HV) which is subject to external bounded disturbance. Different from conventional predictive control, a predictive controller based on sliding mode technology is adopted to reduce the online calculation for the HV system. To eliminate the negative impact caused by the unknown bounded disturbance, a disturbance observer is employed in this paper. Then, a sliding mode controller is presented to compensate the estimation errors. It is proved with the Lyapunov analysis that the predictive sliding mode controller ensures the rigorous stability of the closed-loop system. By means of the simulation results, the proposed control scheme achieving satisfactory performance for the tracking control of the HV system are demonstrated.