CSTR plays a vital role in almost all the chemical industries. Continuous stirred tank reactor (CSTR) is a highly nonlinear process exhibiting stable and unstable steady state at different regions. Control of CSTR in the complete range is a mind boggling problem. In this paper, a fuzzy scheduled pole placement based state feedback control of CSTR is investigated. The entire region is divided into three regions; low, middle and the high region. The low and the high region have stable steady state and the middle region have unstable steady state. Initially, the gain matrix of the state feedback controller is computed for each region using pole placement technique. Then using fuzzy gain scheduler, the complete controller is formed. The result shows the feasibility of using the proposed controller for the control of CSTR. In this chapter optimal control of CSTR is investigated for the tracking and regulatory problems.