The dynamic monitoring of vivo blood glucose acts an important role for diabetic patients to ensure timely healthcare and help to prevent from multiple complications caused by diabetes. This report describes a new non-enzyme glucose sensor based on wireless quartz crystal microbalance (QCM) that can be adapted for use in implanted devices. The chitosan-based enzyme-free boronic-acid glucose sensor improves biocompatibility considering for future vivo implanting. The optimal response of the sensor is in chitosan: 4-Formylphenylboronic acid (4-FPBA) =3:2. In the case of pH 7.4, the sensor has good linear response to glucose and selectivity of sensor to fructose, mannose, urea, and lactic acid performs well under physiological conditions. At physiological temperature, the linear response was also repeated and the average response time was about 4 min. The characteristics of this sensor indicate that it can be applied to dynamic monitoring of implantable blood glucose concentrations.