High voltage pulse generators are commonly used in water treatment applications. In this paper, a high voltage pulse generator with closed loop control on its output voltage is presented. The high-voltage pulse generator is based on the employment of Capacitor-Diode Voltage Multipliers (CDVM) centrally fed from dc-dc boost converter. The generator provides transformer-less operation and high-voltage gain with relatively low voltage rating components which reduces size, and enhances the overall efficiency. A detailed design of the generator passive elements has been presented in this work. Simulation and experimental results are presented to validate the proposed concept.