This review focuses on the advances in development of in-vivo microbiosensors in last five years. Many of the in-vivo microsensors that sometimes are loosely termed “biosensors,”but that don't contain biological recognition elements. For example, in-vivo real-time detection of nitric oxide, non-enzymatic electrochemical sensors using direct oxidation of glucose on the electrode surface that don't have biological recognition elements (such as enzymes, proteins, oligonucleotides),or boronic acid derivatives based fluorescence glucose sensors fall outside this survey.

Chapter Contents:

• 2.1 Introduction
• 2.2 In-vivo enzymatic biosensors
• 2.2.1 Commercialized continuous glucose monitoring systems (CGMS)
• 2.2.2 In-vivo enzymatic biosensor systems in development
• 2.3 Development of non-enzymatic in-vivo biosensors
• 2.4 Conclusion
• References

Inspec keywords: patient diagnosis; microsensors; electrochemical sensors; organic compounds; electrochemical electrodes; biosensors

Other keywords: in-vivo microsensors; nitric oxide; microbiosensors; electrode surface; glucose oxidation; nonenzymatic electrochemical sensors; biological recognition elements; in-vivo diagnostics; real-time detection

Subjects: Electrochemistry and electrophoresis; Patient diagnostic methods and instrumentation; Biosensors; Chemical sensors; Biosensors; Chemical sensors; Biomedical measurement and imaging; Microsensors and nanosensors; Electrochemical analytical methods