In this chapter, short description of concept being a basis of the method, SPR systems classification, methods for sensor surface functionalization are given; structure of present-day SPR-sensors market is described. Special attention is paid to methods of SPR-sensors miniaturization and to assessment of these methods efficiency for medical applications, including prospects of SPR-sensors use for on-site diagnostics.

Chapter Contents:

• 24.1 Introduction
• 24.2 Principle of SPR-sensors work
• 24.3 Types of SPR-sensors
• 24.3.1 SPR-sensors with prismatic coupling devices (couplers)
• 24.3.2 SPR-sensors with waveguide coupling devices
• 24.3.3 SPR-sensors with diffraction gratings
• 24.3.4 Localized SPR (LSPR)
• 24.4 Analytical parameters of SPR-sensors
• 24.5 Sensor surface functionalization
• 24.5.1 Covalent binding
• 24.5.2 Non-covalent binding
• 24.6 SPR-analysis formats
• 24.7 Mass-produced SPR-sensors
• 24.8 SPR-sensors for non-laboratory diagnostics
• 24.8.1 Commercial portable SPR-sensors
• 24.8.2 Recent works in portable SPR-sensors development
• 24.9 Conclusion
• Acknowledgments
• References

Inspec keywords: biosensors; surface plasmon resonance

Other keywords: miniaturized biosensors; surface plasmon resonance; sensor surface functionalization; SPR systems classification; medical applications

Subjects: Biosensors; Collective excitations (surface states); Biomedical engineering; Biomedical measurement and imaging; Biological engineering and techniques; Biosensors