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Surface plasmon resonance based miniaturized biosensors for medical applications

Surface plasmon resonance based miniaturized biosensors for medical applications

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In this chapter, short description of concept being a basis of the method, SPR systems classification, methods for sensor surface functionalization are given; structure of present-day SPR-sensors market is described. Special attention is paid to methods of SPR-sensors miniaturization and to assessment of these methods efficiency for medical applications, including prospects of SPR-sensors use for on-site diagnostics.

Chapter Contents:

  • 24.1 Introduction
  • 24.2 Principle of SPR-sensors work
  • 24.3 Types of SPR-sensors
  • 24.3.1 SPR-sensors with prismatic coupling devices (couplers)
  • 24.3.2 SPR-sensors with waveguide coupling devices
  • 24.3.3 SPR-sensors with diffraction gratings
  • 24.3.4 Localized SPR (LSPR)
  • 24.4 Analytical parameters of SPR-sensors
  • 24.5 Sensor surface functionalization
  • 24.5.1 Covalent binding
  • 24.5.2 Non-covalent binding
  • 24.6 SPR-analysis formats
  • 24.7 Mass-produced SPR-sensors
  • 24.8 SPR-sensors for non-laboratory diagnostics
  • 24.8.1 Commercial portable SPR-sensors
  • 24.8.2 Recent works in portable SPR-sensors development
  • 24.9 Conclusion
  • Acknowledgments
  • References

Inspec keywords: biosensors; surface plasmon resonance

Other keywords: miniaturized biosensors; surface plasmon resonance; sensor surface functionalization; SPR systems classification; medical applications

Subjects: Biosensors; Collective excitations (surface states); Biomedical engineering; Biomedical measurement and imaging; Biosensors

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