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access icon free Pulmonary toxicity of exposure to nano nickel oxide

© The Institution of Engineering and Technology
Received 17/11/2017, Accepted 28/02/2018, Revised 09/02/2018, Published 01/06/2018

Many articles have been reported in the literature on the relationship between exposure to nano nickel oxide (NiO) and pulmonary toxicity, but no coherent results have been achieved. This research is aimed at investigating the combined toxicity effects of pulmonary induced by nano NiO using meta-analysis. Data of cell and rat models were retrieved according to included and excluded criteria from 1994 to 2016. Twenty one articles were chosen in the meta-analysis. The standardised mean difference between the exposure and control groups was calculated from the different endpoints in cell and rat models, respectively. The meta-estimate was calculated using the computational equations when the effect size is measured in different scales. The results found that nano NiO induced the increasing of lactate dehydrogenase and decreasing of cell viability. We found an abnormal change in bronchoalveolar lavage fluid including the raised number of total cells, neutrophils, alveolar macrophage, and chemokines, as well as the transient increasing of pro-inflammation cytokines. In addition, most of the above-mentioned indicators can be changed after exposure to nano NiO from 1 week to 3 months and recovering at 6 months. Nano NiO could induce pulmonary toxicity, hinting potential adverse effect on the human respiratory system.

Inspec keywords: cellular biophysics; nanostructured materials; enzymes; size effect; molecular biophysics; toxicology; nickel compounds; pneumodynamics

Other keywords: standardised mean difference; cell data; cell viability; combined toxicity effects; size effect; pulmonary toxicity; in vitro experiments; chemokines; nanonickel oxide exposure; human respiratory system; lactate dehydrogenase; pro-inflammation cytokines; alveolar macrophage; computational equations; neutrophils; time 1 week to 3 month; NiO; rat models; bronchoalveolar lavage fluid; meta-analysis

Subjects: Cellular biophysics; Biomolecular interactions, charge transfer complexes; Haemodynamics, pneumodynamics

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http://iet.metastore.ingenta.com/content/journals/10.1049/mnl.2017.0802
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