Albumin nanoparticles fabricated from microscaled PLGA templates using layer-by-layer assembly
- Author(s): Qi Zhao 1 ; Zhe-Xiang Fang 1 ; Ming-Mao Chen 1 ; Min Li 2 ; Zhi-Min Zhou 2 ; Bo Du 2 ; Qi-Qing Zhang 1, 2
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View affiliations
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Affiliations:
1:
Institute of Biomedical and Pharmaceutical Technology, Fuzhou University , Fuzhou 350002 , People's Republic of China ;
2: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials , Tianjin 300192 , People's Republic of China
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Affiliations:
1:
Institute of Biomedical and Pharmaceutical Technology, Fuzhou University , Fuzhou 350002 , People's Republic of China ;
- Source:
Volume 13, Issue 6,
June
2018,
p.
835 – 837
DOI: 10.1049/mnl.2017.0696 , Online ISSN 1750-0443
The size of particles is a principal parameter to design drug delivery vehicles. In this work, albumin nanoparticles were fabricated from microscaled poly[lactic-co-(glycolic acid)] (PLGA) templates using layer-by-layer (LbL) assembly, which are different from traditional LbL-based hollow capsules. The albumin nanoparticles exhibit a spherical shape and solid inner structure. The formation mechanism of these albumin nanoparticles was proposed based on PLGA templates, mechanical property of albumin and external sonication.
Inspec keywords: drug delivery systems; nanomedicine; nanoparticles; elastic moduli; nanofabrication; biomedical materials; self-assembly; particle size; proteins
Other keywords: hollow capsules; particle size; elastic modulus; poly[lactic-co-(glycolic acid)]; drug delivery vehicles; mechanical property; solid inner structure; layer-by-layer assembly; microscaled PLGA templates; external sonication; spherical surface; albumin nanoparticles
Subjects: Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Self-assembly in nanofabrication; Nanotechnology applications in biomedicine; Biomedical materials; Elasticity and anelasticity; Elasticity, elastic constants; Patient care and treatment
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