Polylysine-modified titania nanotube arrays for local drug delivery
- Author(s): Tao Zhang 1 ; Yan Liu 2 ; Fengfen Zhang 2 ; Xiufeng Xiao 2
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View affiliations
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Affiliations:
1:
Department of Orthopedics Institute , Fuzhou Second Hospital , Fuzhou 350007 , People's Republic of China ;
2: Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou 350007 , People's Republic of China
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Affiliations:
1:
Department of Orthopedics Institute , Fuzhou Second Hospital , Fuzhou 350007 , People's Republic of China ;
- Source:
Volume 13, Issue 1,
January
2018,
p.
93 – 95
DOI: 10.1049/mnl.2017.0312 , Online ISSN 1750-0443
A drug delivery system based on ɛ-polylysine-modified titania nanotube (ɛ-PL-TNTs) arrays was prepared. Polylysine on the nanotubes’ surface can effectively bind with alendronate, a drug for the treatment of osteoporosis, through chemical bond. The bonds are fairly stable in an acid environment and cannot easily break up in a physiological environment. The ɛ-PL-TNTs increased the amount of drug loading by 9% in weight. The in vitro release profile of alendronate from ɛ-PL-TNTs showed a significant reduced burst release and an extended overall release of more than 15 days.
Inspec keywords: nanofabrication; drug delivery systems; bonds (chemical); polymers; semiconductor nanotubes; semiconductor materials; nanomedicine; diseases; biomedical materials; titanium compounds
Other keywords: chemical bond; TiO2; acid environment; physiological environment; ε-polylysine-modified titania nanotube arrays; osteoporosis treatment; in vitro release prohle; drug loading; local drug delivery; alendronate
Subjects: Patient care and treatment; Nanotechnology applications in biomedicine; Biomedical materials; Patient care and treatment
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