access icon free Central composite experimental design for the investigation of the influence of various conditions of anodisation on the amount of antimicrobial agent loaded on TiO2 nanotubes

TiO2 nanotubes on Ti substrate were prepared by electrochemical anodisation method. Central composite experimental design was used to design the experiments to investigate the influence of some variables on the loading of antibiotic gentamicin. A full quadratic model was used in order to find out the influence of the variables and their possible interactions and finally to estimate the optimum conditions. Titanium rods were anodised in ethylene glycol containing different amounts of ammonium fluoride and water at different voltages and different anodising times. Antibacterial activity of the nanotubes prepared under the optimum condition was evaluated by a culture test with Staphylococcus aureus bacteria.

Inspec keywords: microorganisms; nanofabrication; electrochemistry; titanium; titanium compounds; antibacterial activity; anodisation; nanotubes

Other keywords: Ti; TiO2; antimicrobial agent; titanium substrate; titanium rods; culture test; ethylene glycol; antibacterial activity; titania nanotubes; central composite experimental design; quadratic model; ammonium fluoride; antibiotic gentamicin; electrochemical anodisation; water; Staphylococcus aureus bacteria

Subjects: Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Surface treatment and degradation of metals and alloys; Other methods of nanofabrication; Low-dimensional structures: growth, structure and nonelectronic properties; Electrochemistry and electrophoresis

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