Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery

Jacob Gold Bernstein; Brian Douglas Allen; Alexander A. Guerra; Edward Stuart Boyden

Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery

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Author(s): Jacob Gold Bernstein^{1, 2} ; Brian Douglas Allen^{1, 2} ; Alexander A. Guerra¹ ; Edward Stuart Boyden^{1, 2, 3}
- Affiliations: 1: The MIT Media Lab , Massachusetts Institute of Technology , Cambridge , MA 02139 , USA ;
  2: Department of Brain and Cognitive Sciences and MIT McGovern Institute for Brain Research , Massachusetts Institute of Technology , Cambridge , MA 02139 , USA ;
  3: Department of Biological Engineering , Massachusetts Institute of Technology , Cambridge , MA 02139 , USA
Source: Volume 2015, Issue 5, May 2015, p. 177 – 184
DOI: 10.1049/joe.2014.0304 , Online ISSN 2051-3305

This is an open access article published by the IET under the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/)

Received 05/11/2014, Accepted 31/03/2015, Published 09/04/2015

Optogenetics enables light to be used to control the activity of genetically targeted cells in the living brain. Optical fibres can be used to deliver light to deep targets, and light-emitting diodes (LEDs) can be spatially arranged to enable patterned light delivery. In combination, arrays of LED-coupled optical fibres can enable patterned light delivery to deep targets in the brain. Here the authors describe the process flow for making LED arrays and LED-coupled optical fibre arrays, explaining key optical, electrical, thermal and mechanical design principles to enable the manufacturing, assembly and testing of such multi-site targetable optical devices. They also explore accessory strategies such as surgical automation approaches as well as innovations to enable low-noise concurrent electrophysiology.

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Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery

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