RT Journal Article
A1 O. Ebenhöh
A1 T. Handorf
A1 D. Kahn

PB
T1 Evolutionary changes of metabolic networks and their biosynthetic capacities
JN IEE Proceedings - Systems Biology
VO 153
IS 5
SP 354
OP 358
AB The metabolic networks of different species show a large variety in their structural design. In this work, the evolution of functional properties of metabolism in relation with metabolic network structure is investigated. The metabolism of ancestral species is inferred from the metabolism of contemporary species using a Bayesian network model for metabolism evolution. Subsequently, these networks are analysed with the recently developed method of network expansion. This method allows for a structural analysis of metabolic networks as well as a quantification of network functions in terms of their synthesising capacities when they are provided with certain external resources. The evolutionary dynamics of one particular network function: the metabolic expansion of glucose is investigated.
K1 Bayesian network mode
K1 metabolism evolution
K1 structural analysis
K1 network expansion
K1 biosynthetic capacities
K1 evolutionary changes
K1 glucose
K1 metabolic networks
DO https://doi.org/10.1049/ip-syb:20060014
UL https://digital-library.theiet.org/;jsessionid=96u169obhlm1.x-iet-live-01content/journals/10.1049/ip-syb_20060014
LA English
SN 1741-2471
YR 2006
OL EN