Evolutionary changes of metabolic networks and their biosynthetic capacities

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© The Institution of Engineering and Technology
Published 14/07/2012

Abstract

The metabolic networks of different species show a large variety in their structural design. In this work, the evolution of functional properties of metabolism in relation with metabolic network structure is investigated. The metabolism of ancestral species is inferred from the metabolism of contemporary species using a Bayesian network model for metabolism evolution. Subsequently, these networks are analysed with the recently developed method of network expansion. This method allows for a structural analysis of metabolic networks as well as a quantification of network functions in terms of their synthesising capacities when they are provided with certain external resources. The evolutionary dynamics of one particular network function: the metabolic expansion of glucose is investigated.

Inspec keywords: evolution (biological); blood; physiological models; Bayes methods; biochemistry; molecular biophysics

Other keywords: Bayesian network mode; structural analysis; metabolism evolution; network expansion; biosynthetic capacities; evolutionary changes; glucose; metabolic networks

Subjects: General, theoretical, and mathematical biophysics; Probability theory, stochastic processes, and statistics; Biomolecular structure, configuration, conformation, and active sites; Model reactions in molecular biophysics

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