%0 Electronic Article %A M.G. Poolman %A B.K. Bonde %A A. Gevorgyan %A H.H. Patel %A D.A. Fell %K reactions %K post-genomic era %K biochemical information %K metabolic network reconstruction %K individual compounds %K BioCyc database %K KEGG database %K public databases %K enzymes %X In the post-genomic era, the biochemical information for individual compounds, enzymes, reactions to be found within named organisms has become readily available. The well-known KEGG and BioCyc databases provide a comprehensive catalogue for this information and have thereby substantially aided the scientific community. Using these databases, the complement of enzymes present in a given organism can be determined and, in principle, used to reconstruct the metabolic network. However, such reconstructed networks contain numerous properties contradicting biological expectation. The metabolic networks for a number of organisms are reconstructed from KEGG and BioCyc databases, and features of these networks are related to properties of their originating database. %@ 1741-2471 %T Challenges to be faced in the reconstruction of metabolic networks from public databases %B IEE Proceedings - Systems Biology %D September 2006 %V 153 %N 5 %P 379-384 %I %U https://digital-library.theiet.org/;jsessionid=1x77mlq18p9b4.x-iet-live-01content/journals/10.1049/ip-syb_20060012 %G EN