Differential coding of humoral stimuli by timing and amplitude of intracellular calcium spike trains

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Differential coding of humoral stimuli by timing and amplitude of intracellular calcium spike trains

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The ubiquitous Ca2+-phosphoinositide pathway transduces extracellular signals to cellular effectors. Using a mathematical model, we simulated intracellular Ca2+ fluctuations in hepatocytes upon humoral stimulation. We estimated the information encoded about random humoral stimuli in these Ca2+–spike trains using an information-theoretic approach based on stimulus estimation methods. We demonstrate accurate transfer of information about random humoral signals with low temporal cutoff frequencies. In contrast, our results suggest that high-frequency stimuli are poorly transduced by the transmembrane machinery. We found that humoral signals are encoded in both the timing and amplitude of intracellular Ca2+ spikes. The information transmitted per spike is similar to that of sensory neuronal systems, in spite of several orders of magnitude difference in firing rate.

Inspec keywords: physiological models; neurophysiology; cellular biophysics; bioelectric phenomena; biomembranes; information theory; calcium

Other keywords: Ca; information theory; hepatocytes; sensory neuronal systems; firing rate; ubiquitous Ca2+-phosphoinositide pathway; intracellular calcium spike trains; differential humoral stimuli coding; mathematical model; extracellular signals; cellular effectors; stimulus estimation

Subjects: Bioelectricity; Biological transport; cellular and subcellular transmembrane physics; Electrical activity in neurophysiological processes; General, theoretical, and mathematical biophysics; Natural and artificial biomembranes

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