The ubiquitous Ca2+-phosphoinositide pathway transduces extracellular signals to cellular effectors. Using a mathematical model, we simulated intracellular Ca2+ fluctuations in hepatocytes upon humoral stimulation. We estimated the information encoded about random humoral stimuli in these Ca2+–spike trains using an information-theoretic approach based on stimulus estimation methods. We demonstrate accurate transfer of information about random humoral signals with low temporal cutoff frequencies. In contrast, our results suggest that high-frequency stimuli are poorly transduced by the transmembrane machinery. We found that humoral signals are encoded in both the timing and amplitude of intracellular Ca2+ spikes. The information transmitted per spike is similar to that of sensory neuronal systems, in spite of several orders of magnitude difference in firing rate.
References
-
-
1)
-
R.E. Dolmetsch ,
K. Xu ,
R.S. Lewis
.
Calcium oscillations increase the efficiency and specificity of gene expression.
Nature
,
933 -
936
-
2)
-
F. Tang ,
E.W. Dent ,
K. Kalil
.
Spontaneous calcium transients in developing cortical neurons regulate axon outgrowth.
J. Neurosci.
,
927 -
936
-
3)
-
M.J. Berridge ,
M.D. Bootman ,
H.L. Roderick
.
Calcium signalling: dynamics, homeostasis and remodelling.
Nat. Rev. Mol. Cell Biol.
,
517 -
529
-
4)
-
N.M. Woods ,
K.S. Cuthbertson ,
P.H. Cobbold
.
Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes.
Nature
,
600 -
602
-
5)
-
P.E. Rapp ,
M.J. Berridge
.
The control of transepithelial potential oscillations in the salivary gland of Calliphora erythrocephala.
J. Exp. Biol.
,
119 -
132
-
6)
-
C. Schöfl ,
G. Brabant ,
R.D. Hesch ,
A. von zur Muhlen ,
P.H. Cobbold ,
K.S. Cuthbertson
.
Temporal patterns of alpha 1-receptor stimulation regulate amplitude and frequency of calcium transients.
Am. J. Physiol.
,
1030 -
1036
-
7)
-
M.J. Berridge
.
The AM and FM of calcium signalling.
Nature
,
759 -
760
-
8)
-
F. Gabbiani ,
C. Koch ,
C. Koch ,
I. Segev
.
(1998)
Principles of spike train analysis, Methods in neuronal modeling.
-
9)
-
T.R. Chay ,
Y.S. Lee ,
Y.S. Fan
.
Appearance of phase-locked Wenckebach-like rhythms, devil's staircase and universality in intracellular calcium spikes in non-excitable cell models.
J. Theor. Biol.
,
21 -
44
-
10)
-
G. Brabant ,
K. Prank ,
C. Schöfl
.
Pulsatile patterns in hormone secretion.
Trends Endocrinol. Metab.
,
183 -
190
-
11)
-
C. Shannon ,
W. Weaver
.
(1949)
The mathematical theory of communication.
-
12)
-
F. Gabbiani
.
Coding of time-varying signals in spike trains of linear and half-wave rectifying neurons.
Comp. Neural. Syst.
,
61 -
85
-
13)
-
F. Gabbiani ,
C. Koch
.
Coding of time-varying signals in spike trains of integrate-and-fire neurons with random threshold.
Neural Comput.
,
44 -
66
-
14)
-
H.V. Poor
.
(1988)
An introduction to signal detection and estimation.
-
15)
-
R.E. Dolmetsch ,
R.S. Lewis ,
C.C. Goodnow ,
J.I. Healy
.
Differential activation of transcription factors induced by Ca2+ response amplitude and duration.
Nature
,
855 -
858
-
16)
-
T.M. Gomez ,
E. Robles ,
M. Poo ,
N.C. Spitzer
.
Filopodial calcium transients promote substrate-dependent growth cone turning.
Science
,
1983 -
1987
-
17)
-
C. Schöfl ,
C. Becker ,
K. Prank ,
A. Von Zur Mühlen ,
G. Brabant
.
Twenty-four-hour rhythms of plasma catecholamines and their relation to cardiovascular parameters in healthy young men.
Eur. J. Endocrinol.
,
675 -
683
-
18)
-
W. Bialek ,
F. Rieke
.
Reliability and information transmission in spiking neurons.
Trends. Neurosci.
,
428 -
434
-
19)
-
W. Bialek ,
F. Rieke ,
R.R. de Ruyter van Steveninck ,
D. Warland
.
Reading a neural code.
Science
,
1854 -
1857
-
20)
-
F. Rieke ,
D. Warland ,
W. Bialek
.
Coding efficiency and information rates in sensory neurons.
Europhys. Lett.
,
151 -
156
-
21)
-
R. Wessel ,
C. Koch ,
F. Gabbiani
.
Coding of time-varying electric field amplitude modulations in a wave-type electric fish.
J. Neurophysiol.
,
2280 -
2293
http://iet.metastore.ingenta.com/content/journals/10.1049/ip-syb_20050040
Related content
content/journals/10.1049/ip-syb_20050040
pub_keyword,iet_inspecKeyword,pub_concept
6
6