An anti-jamming model is set up for the high dynamic global positioning system (GPS) receiver embedded in a high-speed vehicle. With a view to identify the characteristics of interferences in high dynamic condition and the shortcomings of traditional null widening methods, a novel statistical space–time null widening (SSTNW) method is proposed in this study. The SSTNW method can suppress interferences effectively in high dynamic conditions and can remove disturbance by nonideal factors, i.e. it improves the robustness of the anti-jamming algorithm of the high dynamic GPS receiver remarkably. At the same time, in view of the characteristics of space–time adaptive processing (STAP), a novel orthogonal constraint STAP is proposed to solve the distortion of the GPS signal in STAP. Simulation tests validate the feasibility and effectiveness of the proposed algorithm.